依达拉奉对脑损伤治疗机制及临床应用的研究进展  

Research Progress in Therapeutic Mechanism and Clinical Application of Edaravone in Brain Injury

作　　者：康传依 胡晓蕊 王晓红[1] 程畅 卢佳[1] 王怀志[1] 刘蕾[1] 胡建[1] 赵娜[1] KANG Chuanyi;HU Xiaorui;WANG Xiaohong;CHENG Chang;LU Jia;WANG Huaizhi;LIU Lei;HU Jian;ZHAO Na(Department of Psychiatry,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院精神科,哈尔滨150001

出　　处：《医学综述》2022年第6期1133-1138,共6页Medical Recapitulate

基　　金：国家重点研发计划(2018YFC1314400,2018YFC1314402)。

摘　　要：依达拉奉是一种自由基清除剂、抗氧化剂,对多种神经系统疾病所致的脑损伤均能发挥治疗及保护作用,目前多在神经系统疾病尤其是脑梗死的治疗中广泛应用。然而,因神经元的自身再修复能力有限,临床上对于多种疾病导致的脑损伤一直缺乏有效的治疗手段。作为神经系统疾病新的治疗药物,依达拉奉在其他脑损伤疾病中应用的可能性受到广泛关注,且可能发挥神经保护作用。未来,在基础研究与临床研究的基础上,更多依达拉奉治疗脑损伤疾病的循证医学证据的发现将为疾病治疗提供新方向。Edaravone,as a free radical scavenger and antioxidant,can play a therapeutic and protective role in brain injury caused by various neurological diseases,and is currently widely used in the treatment of neurological diseases,especially cerebral infarction.However,due to the limited ability of neurons to repair themselves,there has been a lack of effective treatment for brain injury caused by various diseases in clinical practice.As a new therapeutic drug for neurological diseases,the possibility of edaravone′s application in other brain injury diseases has drawn much attention,which may play a neuroprotective role.In the future,more evidence-based medical evidence of edaravone for the treatment of brain injury diseases will be discovered based on basic and clinical research,to propose new directions for the disease treatment.

关 键 词：脑损伤 依达拉奉 神经退行性疾病 缺血性脑损伤 出血性脑损伤 

分 类 号：R749[医药卫生—神经病学与精神病学]