脑源性神经营养因子治疗卒中后认知功能障碍的研究进展  

A review on treating post-stroke cognitive impairment with brain derived neurotrophic factor

作　　者：杨秀芬 孙丰翠 张风霞[2] YANG Xiufen

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250014

出　　处：《中医临床研究》2022年第5期141-145,共5页Clinical Journal Of Chinese Medicine

基　　金：国家自然科学基金(81573945);国家中医药管理局王新陆全国名中医工作室(鲁财社指[2016]47);山东省科技计划(2013GSF11902);山东省中医药科技发展项目(2013-081)(2019-0093)。

摘　　要：脑源性神经营养因子(Brain Derived Neurotrophic Factor,BDNF)/酪氨酸激酶受体B(Tropomyosin Receptor Kinase B,TrkB)信号通路是人体内重要的细胞信号通路。它参与细胞的存活和分化、突触可塑性和神经再生等重要的活动。卒中后认知功能障碍(Post-stroke Cognitive Impairment,PSCI)的恢复在很大程度上受到这类通路的调节。文章对BDNF对PSCI的治疗及其相关通路进行综述,旨在为PSCI的靶向治疗提供理论依据和新的方法。Brain derived neurotrophic factor/Tropomyosin receptor kinase B pathways are greatly important cellar signal pathways in human beings.These pathways were involved in many essentially cellar activities,such as cellar survival and differentiation,synaptic plasticity and neurogenesis.The recovery of post-stroke cognitive impairment is regulated by these pathways to a large extent.This paper reviews the effect of BDNF on post-stroke cognitive impairment and related pathways,aiming at providing basic theory and new methods for target therapy of PSCI.

关 键 词：卒中后认知功能障碍 脑源性生长因子 酪氨酸激酶受体B 记忆 

分 类 号：R743.3[医药卫生—神经病学与精神病学]