自噬在胶质母细胞瘤发生发展中的作用  

The impact of autophagy during the development and survival of glioblastoma

作　　者：张鲁(综述) 靳峰(审校) ZHANG Lu;JIN Feng(School of Clinical Medicine,Jining Medical University,Jining 272013 China;Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,济宁272013 [2]济宁医学院附属医院,济宁272029

出　　处：《济宁医学院学报》2022年第2期131-134,共4页Journal of Jining Medical University

基　　金：济宁医学院教师科研扶持基金(JYFC2018FKJ139)。

摘　　要：自噬是细胞内维持稳态和保护细胞在应激条件下免于死亡的过程,通过溶酶体途径降解受损细胞器及错误折叠的蛋白质发挥作用。自噬在胶质母细胞瘤(GBM)中发生频繁,可导致长期化疗后多药耐药(multidrug resistance,MDR)。自噬在胶质瘤及MDR细胞中发挥双重作用,既参与其发生发展,同时也能清除凋亡抑制的肿瘤细胞。本文综述了自噬在GBM发生及发展中的作用,总结了影响自噬的相关信号通路,探讨自噬调节作为一种肿瘤治疗策略的可行性。Autophagy is a process of maintaining homeostasis and protecting cells from death under stress.It can degrade damaged organelles and misfolded proteins through lysosomal pathway.Autophagy not only occurs frequently in glioblastoma,but also easily leads to multidrug resistance(MDR)after long-term chemotherapy.Autophagy plays a dual role in tumor and MDR cells as it can not only participate in its occurrence and development,but also eliminate apoptosis inhibitory cells.This paper reviews the role of autophagy in the occurrence and development of glioblastoma,summarizes the related signal pathways affecting autophagy,and discusses the feasibility of autophagy regulation as a tumor treatment strategy.

关 键 词：胶质母细胞瘤 自噬 多药耐药 

分 类 号：R739.41[医药卫生—肿瘤]