瘢痕疙瘩的遗传及局部微环境病因学研究现状  

Advances in Genetic and Local Microenvironment Etiology of Keloid

作　　者：黄晓迪 李珍玲[1] 李莲花[1] 李永来 郑振龙[1] 金哲虎[1] HUANG Xiaodi;LI Zhenling;LI Lianhua;LI Yonglai;ZHENG Zhenlong;JIN Zhehu(Department of Dermatology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2022年第3期245-249,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(81960561);吉林省卫生技术创新项目(2017J095)。

摘　　要：瘢痕疙瘩的发病机制复杂,目前对其病因学研究主要围绕遗传因素、环境因素、细胞因素和免疫因素。研究表明,瘢痕疙瘩遗传相关的多个致病基因通过表观遗传学机制,如DNA甲基化、组蛋白修饰和非编码RNA的改变等,能够影响瘢痕疙瘩形成。在此,本文回顾现有的临床和实验研究,分析了有关遗传和局部微环境因素病因的研究现状,以期为瘢痕疙瘩的病因学研究带来新的见解,为瘢痕疙瘩的诊断和治疗奠定基础。Keloid has complex pathogenesis and recent research on its etiology mainly focuses on the genetic,environmental,cellular,and immune factors.Studies have demonstrated that multiple genetically related pathogenic genes in keloids can affect the formation of keloids through epigenetic mechanisms such as DNA methylation,histone acetylation,as well as changes in non-coding RNAs(ncRNAs).This article reviews the clinical and experimental research on the keloid,and further analyzes advances in the effects of genetic and local microenvironmental factors on keloid pathogenesis.It is hopful to provide new insights into the current state of considerations in etiology of keloid,and lay a foundation for the diagnosis and treatment of keloid.

关 键 词：瘢痕疙瘩 病因 遗传 环境 

分 类 号：R739.5[医药卫生—肿瘤]