Bullous eruption as a cutaneous manifestation of eosinophilic granulomatosis with polyangiitis  

作　　者：Paula PTjokrosaputro Tsui YLian Dingyuan Wang Joyce SSLee Chuanhui Xu 

机构地区：[1]Department of Rheumatology,Allergy and Immunology,Tan Tock Seng Hospital,Singapore,Singapore [2]National Skin Centre,Singapore,Singapore

出　　处：《Rheumatology & Autoimmunity》2021年第1期54-57,共4页风湿病与自身免疫（英文）

摘　　要：Cutaneous manifestations are variable in patients with eosinophilic granulomatosis with polyangiitis(EGPA).We report a case where bullous eruption was a presenting manifestation of EGPA.A 55-year-old Chinese man with a background of adult-onset asthma and chronic sinusitis was admitted for a 3-week history of lower limb weakness and a large bulla on his right calf with surrounding erythema.Skin biopsy showed a subepidermal blister with significant dermal eosinophilia,without vasculitis.The patient was diagnosed with EGPA with systemic involvement on the basis of a thorough medical history,eosinophilia,cardiac magnetic resonance imaging showing acute myocarditis,and nerve biopsy with eosinophilic vasculitic neuropathy.He responded well to corticosteroids and rituximab.Nonvasculitic bullous eruptions are rarely described as manifestations of EGPA.Prompt recognition of this entity is crucial for its early diagnosis.

关 键 词：BULLOUS ERUPTION CUTANEOUS EGPA 

分 类 号：R76[医药卫生—耳鼻咽喉科]