沿Blaschko线分布的以孤立结节为主的皮肤假性淋巴瘤1例  

Cutaneous Pseudolymphoma Presented with Solitary Nodules along with Blaschko Lines:A Case Report

作　　者：陈王蔚 周停停 周一彤 吴丹 赵艳霞[1,3] CHEN Wangwei;ZHOU Tingting;ZHOU Yitong;WU Dan;ZHAO Yanxia(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Traditional Chinese Medicine Hospital of Luanping County,Luanping 068250,China;Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine,Tianjin 300120,China)

机构地区：[1]天津中医药大学,天津301617 [2]滦平县中医院,河北滦平068250 [3]天津市中医药研究院附属医院,天津300120

出　　处：《中国皮肤性病学杂志》2022年第2期204-207,共4页The Chinese Journal of Dermatovenereology

基　　金：天津市卫生健康委员会中医药重点领域科研项目(2020004)。

摘　　要：患者女,55岁,左侧胸肋部散在孤立红色结节伴瘙痒1个月余。皮肤科情况:左侧胸肋部可见散在沿Blaschko线分布的多个绿豆大小的孤立红色结节,类半球形,境界清楚,质地中等,表面光滑,浸润明显,轻度瘙痒,无压痛,无鳞屑。皮损组织病理示:表皮棘层变薄,真皮内大量淋巴细胞、浆细胞、组织细胞弥漫性浸润,偶见嗜酸性粒细胞,部分淋巴细胞见核分裂象。免疫组织化学示:CD20(++),CD3(+),CD5(+),CD43(+),Ki-67(GC高表达),CD10(+),Bcl-6(GC+),Bcl-2(GC-),CyclinD1(-);IgH、Igκ基因重排未见克隆性扩增峰。诊断:皮肤假性淋巴瘤。A 55-year-old female presented with scattered solitary nodules on her left sternocostal with itching for more than 1 month.Dermatologic examination showed solitary,red,hemispherical nodules of mungbean size scattered arrangement with Blaschko lines on the left sternocostal,the lesions with clear boundary,medium texture,smooth surface,and without pain or scale.Histopathology showed the atrophied of spinous layer,diffuse infiltrations of lymphocytes,plasma cells and histiocytes in the dermis,with few eosinophils and mitotic in some lymphocytes.Immunohistochemical showed mononuclear cells were partly positive for CD3,CD5,CD43,CD10,Bcl-6,Ki-67,strongly positive for CD20,negative for Bcl-2 and CyclinD1.Gene rearrangement of IgH and Igκ were negative.A diagnosis of cutaneous pseudolymphoma was made.

关 键 词：皮肤假性淋巴瘤 BLASCHKO线 带状疱疹 

分 类 号：R739.5[医药卫生—肿瘤]