Strategies for efficient photothermal therapy at mild temperatures:Progresses and challenges  

作　　者：Peng Gao Hui Wang Yiyun Cheng 

机构地区：[1]South China Advanced Institute for Soft Matter Science and Technology,School of Molecular Science and Engineering,South China University of Technology,Guangzhou 510640,China [2]Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University,Shanghai 200241,China

出　　处：《Chinese Chemical Letters》2022年第2期575-586,共12页中国化学快报（英文版）

基　　金：financially supported by the Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices (No.2019B121203003)。

摘　　要：Photothermal therapy(PTT), typically ablates tumors via hyperthermia generated from photothermal agents(PTAs) under laser irradiation, has attracted great attentions in the past decades. Unfortunately,longstanding, frequent and high-power density laser irradiations are needed to maintain the hyperthermal status(>50 ℃) for efficient therapy, which will damage the skin and nearby healthy tissues. Suppressing cancer cells with a mild temperature elevation is more attractive and feasible for PTT. Recently,low-temperature photothermal therapy(LTPTT), which could inhibit tumor under mild hyperthermia, has been widely investigated by researchers. Herein, we systematically summarized the strategies to achieve LTPTT. Diverse PTAs including organic and inorganic materials reported for LTPTT were introduced. The established strategies for LTPTT were intensively described. Finally, the challenges as well as future perspectives in this field were discussed.

关 键 词：Photothermal therapy Mild hyperthermia Photothermal agents NANOMEDICINE Tumor targeted therapy 

分 类 号：R730.5[医药卫生—肿瘤]