适形调强放疗联合顺铂为基础的化疗对≥5 cm非小细胞肺癌患者生存质量和血清肿瘤标志物的影响  

Effect of Intensity Modulated Radiation Therapy Combined with Cisplatin Based Chemotherapy on Quality of Life and Serum Tumor Markers in Patients with Non-small Cell Lung Cancer≥5 cm

作　　者：苏旭军[1] 叶建明[2] 钱洪[1] 程小飞[1] 张扬[1] SU Xu-jun;YE Jian-min;QIAN Hong;CHENG Xiao-fei;ZHANG Yang(Department of Internal Medicine-Oncology,Anqing Hospital of Chinese People's Liberation Army Navy,Anqing,Anhui,246000,China;Department of Oncology,The First Affiliated Hospital ofGannan Medical College,Ganzhou,Jiangxi,341000,China)

机构地区：[1]中国人民解放军海军安庆医院肿瘤内科,安徽安庆246000 [2]赣南医学院第一附属医院肿瘤科,江西赣州341000

出　　处：《现代生物医学进展》2022年第5期914-918,共5页Progress in Modern Biomedicine

基　　金：江西省卫生计生委科技计划项目(20151172)。

摘　　要：目的:探讨适形调强放疗联合顺铂为基础的化疗治疗≥5 cm非小细胞肺癌(NSCLC)的疗效及对生存质量和血清肿瘤标志物的影响。方法:选取2016年1月~2019年1月来我院就诊的60例NSCLC患者(肿瘤直径≥5 cm)。分组方法采用随机数字表法,分为对照组(适形调强放疗)和观察组(适形调强放疗联合顺铂为基础的化疗治疗),各30例。对比两组疗效、生存质量、1年生存率、血清肿瘤标志物和不良反应发生情况。结果:观察组治疗后的生存质量优于对照组(P<0.05)。观察组治疗后的总有效率为63.33%(19/30),高于对照组的36.67%(11/30)(P<0.05)。治疗后,两组神经元烯醇化酶(NSE)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA21-1)较治疗前下降,且观察组低于对照组(P<0.05)。观察组的1年生存率66.67%高于对照组36.67%(P<0.05)。两组放射性肺炎、放射性食管炎的发生率组间对比无差异(P>0.05)。观察组的全身不良反应、血液毒性发生率高于对照组(P<0.05)。结论:适形调强放疗联合顺铂为基础的化疗治疗≥5 cm NSCLC患者,疗效较好,可有效控制疾病进展,提高患者生存率。Objective:To investigate the efficacy of intensity modulated radiation therapy combined with cisplatin based chemotherapy in the treatment of non-small cell lung cancer(NSCLC)≥5 cm and its influence on the quality of life and serum tumor markers.Methods:60 patients with NSCLC(tumor diameter≥5 cm)from January 2016 to January 2019 were selected.the patients were randomly divided into control group(IMRT)and observation group(IMRT combined with cisplatin based chemotherapy),30 cases in each group.The efficacy,quality of life,1-year survival rate,serum tumor markers and adverse reactions were compared between the two groups.Results:The quality of life in the observation group was better than that in the control group(P<0.05).The total effective rate of the observation group was 63.33%(19/30),which was higher than 36.67%(11/30)of the control group(P<0.05).After treatment,the levels of neuron enolase(NSE),carbohydrate antigen 199(CA199),cytokeratin 19 fragment(CYFRA21-1)in the observation group were lower than those in the control group(P<0.05).The 1-year survival rate of the observation group was 66.67%,which was higher than 36.67%of the control group(P<0.05).There was no difference in the incidence of radiation pneumonia and radiation esophagitis between the two groups(P>0.05).The incidence of systemic adverse reactions and hematotoxicity in the observation group was higher than that in the control group(P<0.05).Conclusion:Intensity modulated radiation therapy combined with cisplatin based chemotherapy in the treatment of NSCLC patients with≥5 cm is effective,which can effectively control the disease progression and improve the survival rate of patients.

关 键 词：适形调强放疗 顺铂 非小细胞肺癌 疗效 生存质量 血清肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]