末端炔基单膦配体在不对称氢化反应中的应用  

Application of Alkyl-terminated Monodentate Phosphorus Ligand in Asymmetric Hydrogenation

作　　者：丰检 欧阳华[1] 张凤[1] Feng Jian;Ouyang Hua;Zhang Feng(School of Chemistry and Materials Science,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学化学与材料科学院,湖南长沙410128

出　　处：《山东化工》2022年第6期1-3,6,共4页Shandong Chemical Industry

基　　金：国家自然科学基金资助项目(21302051);湖南省自然科学基金资助项目(14JJ3091)。

摘　　要：单膦配体具有结构稳定、易于合成等优点,在不对称催化反应中有着广泛的应用。具有回收潜力的高效单膦催化剂对于科研工作者有着十分重要的意义。优化反应条件后,我们将含炔基的手性亚磷酰胺酯配体应用于铑催化的(Z)-2-乙酰氨基肉桂酸甲酯类底物的不对称氢化反应中,取得了高达90%ee值,为“点击化学”方法制备负载及可回收催化剂奠定了基础。Chiral monodentate phosphorus ligands have been widely used in catalytic asymmetric reactions due to their stable structure and facile synthesis.The highly efficient monodentate phosohorus catalysts,which are feasible to be recycled,are of great importance for researchers.Herein,an alkyl-terminated chiral monodentate phosphorous ligand was applied it to the Rh-catalyzed asymmetric hydrogenation of a series of(Z)-methyl-2-acetamidocinnamate under optimized reaction conditions and up to 90%ee was obtained.This work lays the foundation for the synthesis of recyclable supported asymmetric hydrogenation catalysts via“click chemistry”.

关 键 词：手性亚磷酰胺酯 末端炔基 不对称氢化 铑催化 

分 类 号：O643.3[理学—物理化学]