阿司匹林预防子痫前期-子痫发作风险的研究  

Study of Aspirin in Preventing the Risk of Preeclampsia-eclampsia

作　　者：贾利红 曹丹丹 黎玉香 Jia Lihong;Cao Dandan;Li Yuxiang(Department of Obstetrics,Huizhou No.1 Maternal and Child Health Care Hospital,Huizhou 516000)

机构地区：[1]惠州市第一妇幼保健院产科一区,惠州516000 [2]惠州市第一妇幼保健院产房,惠州516000

出　　处：《数理医药学杂志》2022年第4期551-553,共3页Journal of Mathematical Medicine

基　　金：2019年度惠州市医疗卫生类科技计划项目“阿司匹林预防子痫前期-子痫发作风险的研究”(惠市科字[2019]105号-2019Y123)。

摘　　要：目的:分析阿司匹林预防子痫前期-子痫发作风险的应用价值。方法:选取2019年5月~2021年4月于某院产科门诊定期产检的子痫前期-子痫高危因素孕妇104例作为研究对象,采用随机数字表达法将其分为实验组和对照组各52例,对照组给予孕期营养指导、体重管理、补钙,实验组在此基础上给予阿司匹林进行干预。对比两组患者妊娠结局、子痫发病率、妊娠情况和母体并发症发生率。结果:实验组患者早产率和子痫发病率显著低于对照组,实验组患者足月产率显著高于对照组,实验组患者分娩孕周及新生出生体重均显著高于对照组,实验组患者胎盘早剥、产后出血、肝功能异常等并发症总发生率均显著低于对照组,差异均具有统计学意义(P<0.05)。两组流产率比较差异无统计学意义(P>0.05)。结论:针对合并子痫高危因素的孕妇,应用阿司匹林对患者进行干预,可有效降低子痫发作风险,延长患者孕周及改善妊娠结局等作用效果,具有较高的临床推广应用价值。Objective:To analyze the application value of aspirin in preventing preeclampsia-eclampsia risk.Methods:A total of 104 pregnant women with high risk factors for preeclampsia-eclampsia who received regular obstetric check-ups in a hospital from May 2019 to April 2021 were selected as the research objects.The patients were divided into experimental group(n=52)and the control group(n=52)by random number table method.Patients in the control group were given nutrition guidance,weight management,and calcium supplementation during pregnancy,and patients in the experimental group were given aspirin for intervention on this basis.The pregnancy outcomes,eclampsia incidence,pregnancy status and incidence of maternal complications in the two groups were compared.Results:The premature birth rate and the incidence of eclampsia in the experimental group were significantly lower than those in the control group,and the term birth rate in the experimental group was significantly higher than that in the control group.The birth pregnancy week and new birth weight were significantly higher than those of the control group,and the total incidence of complications such as placental abruption,postpartum hemorrhage and abnormal liver function were significantly lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the abortion rate between the two groups(P>0.05).Conclusion:For pregnant women complicated with high-risk factors for eclampsia,the application of intervention of aspirin in patients can effectively reduce the risk of eclampsia,prolong the gestational week of patients and improve the pregnancy outcomes,which has high clinical promotion and application value.

关 键 词：阿司匹林 子痫前期 发作风险 

分 类 号：R749.1[医药卫生—神经病学与精神病学]