基于间质表皮转化因子/肝细胞生长因子信号通路靶向分子成像探针研究进展  

Research progresses of targeted molecular imaging probes based on c-mesenchymal-epithelial transition factor/hepatocyte growth factor signal pathway

作　　者：柯明星 韩兆国[1,2] 孙夕林[1,2] KE Mingxing;HAN Zhaoguo;SUN Xilin(Department of Nuclear Medicine,the Fourth Hospital of Harbin Medical University,Harbin 150001,China;NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics,Molecular Imaging Research Center(MIRC)of Harbin Medical University,Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院核医学科,黑龙江哈尔滨150001 [2]哈尔滨医科大学分子影像研究中心,黑龙江哈尔滨150028

出　　处：《中国医学影像技术》2022年第4期624-627,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81627901)。

摘　　要：间质表皮转化因子(c-Met)/肝细胞生长因子(HGF)信号通路在肿瘤发生、发展中起重要作用。分子成像可准确、无创地评价关键分子靶点在体表达水平和活化状态。基于c-Met的肿瘤靶向分子成像不仅可检测c-Met表达状态以筛选受益患者,还能监测治疗效果、评估预后,提高靶向治疗效果。本文就基于c-Met/HGF信号通路的靶向分子成像探针研究进展进行综述。C-mesenchymal-epithelial transition factor(c-Met)/hepatocyte growth factor(HGF)signal pathway plays an important role in tumorigenesis and development.Molecular imaging can accurately and non-invasively evaluate the in vivo expression level and activation status of key molecular targets.Molecular imaging based on c-Met for tumors could not only detect the expression status of c-Met to screen beneficial patients,but also monitor therapeutic effect and evaluate prognosis,hence improving the effect of targeted therapy.The research progresses of targeted molecular imaging probes based on c-Met/HGF signaling pathway were reviewed in this article.

关 键 词：分子探针技术 分子成像 间质表皮转化因子 肝细胞生长因子 

分 类 号：R73[医药卫生—肿瘤] R445[医药卫生—临床医学]