浙产藏红花单方联合氟西汀治疗产后抑郁症的临床疗效观察  

Observation on the clinical efficacy of single drug prescription of saffron from Zhejiang province combined with fluoxetine in the treatment of postpartum depression

作　　者：张文渊[1] 丁盛娣[1] 李丽琴[2] ZHANG Wenyuan;DING Shengdi;LI Liqin(Department of Obstetrics and Gynecology,Huzhou Central Hospital,Huzhou 313000,China;Department of Central Laboratory,Huzhou Central Hospital,Huzhou 313000,China)

机构地区：[1]湖州市中心医院妇产科,浙江湖州313000 [2]湖州市中心医院中心实验室,浙江湖州313000

出　　处：《中国现代医生》2022年第6期148-152,共5页China Modern Doctor

基　　金：国家自然科学基金青年科学基金项目(31600255);浙江省湖州市科技局公益性应用研究项目(2017GYB18)。

摘　　要：目的观察浙产藏红花单方联合氟西汀治疗产后抑郁症(PPD)的临床疗效及相关神经递质和激素的变化。方法选取2017年1月至2020年3月湖州市中心医院收治的80例PPD患者,随机对照双盲法分为两组,对照组予氟西汀全量治疗,共20例;治疗组予浙产藏红花(低剂量、中剂量、高剂量组,各20例)和半量氟西汀治疗,两组疗程皆为8周。比较两组患者用药后疗效及不良反应发生率,检测每组患者用药前及用药8周末血清5-羟色胺(5-HT)、去甲肾上腺素(NA)、雌二醇(E_(2))及孕酮(P)水平。结果对照组有效率为80.0%,治疗组有效率分别为低剂量组85.0%,中剂量及高剂量组均为95.0%。治疗后两组患者血清5-HT、NE、E_(2)较治疗前均明显升高,P较治疗前有明显降低(P<0.01)。四组用药8周末血常规、肝肾功能、大小便常规检查结果显示,治疗组均无异常,对照组有2例轻度肝功能异常。四组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论浙产藏红花单方联合氟西汀治疗PPD临床疗效佳,能有效调整PPD患者血清5-HT、NE、E_(2)及P浓度,中等剂量(500 mg)的藏红花联合半量氟西汀治疗PPD,临床疗效显著,不良反应少,安全性可靠,值得临床推广应用。Objective To observe the clinical efficacy of single drug prescription of saffron from Zhejiang province combined with fluoxetine in the treatment of postpartum depression(PPD)and the changes of related neurotransmitters and hormones.Methods A total of 80 patients with PPD admitted to Huzhou Central Hospital from January 2017 to March 2020 were selected and randomly divided into the control group(n=20)and the treatment group(n=60)by double-blind method.The control group was treated with fluoxetine in full dose,while the treatment group was treated with saffron from Zhejiang province(low-dose,medium-dose and high-dose,n=20 each)and fluoxetine in half dose,in which the course of treatment in both groups was 8 weeks.The efficacy and incidence of adverse reactions(ADRs)after medication were compared between the two groups of patients,and the serum levels of 5-hydroxytryptamine(5-HT),norepinephrine(NA),estradiol(E_(2))and progesterone(P)in each group of patients were detected at baseline and the end of 8 weeks.Results The efficacy rate of the control group was 80.0%,and the treatment group was 85.0%in the low dose group,95.0%in the medium dose group and 95.0%in the high dose group,respectively.After treatment,the levels of serum 5-HT,NE and E_(2) in both groups of patients were significantly higher than those before treatment,and P was significantly lower than that before treatment(P<0.01).In the results of routine examination of blood,hepatic and renal function,urine and stool in the four groups at the end of 8 weeks,there was no abnormality in the treatment group,while there were 2 cases of abnormal liver function in the control group.There was no statistically significant difference in the incidence of ADRs among the four groups.Conclusion Single drug prescription of saffron from Zhejiang province combined with fluoxetine has a good clinical efficacy in treating PPD,which can effectively adjust the serum concentrations of 5-HT,NE,E_(2) and P in patients with PPD.The medium dose(500 mg)of saffron combined with fluox

关 键 词：浙产藏红花 氟西汀 产后抑郁症 神经递质 

分 类 号：R749.4[医药卫生—神经病学与精神病学]