三黄三仙汤治疗脾肾亏虚型晚期乳腺癌患者癌因性疲乏的效果观察  

Effect of Sanhuang Sanxian Decoction on cancer-related fatigue in patients with advanced breast cancer of spleen and kidney deficiency type

作　　者：任莉莉 姚庆华 曹文明 胡轶娟[3] 张永军 张波 蔡鹄 REN Li-li;YAO Qing-hua;CAO Wen-ming;HU Yi-juan;ZHANG Yong-jun;ZHANG Bo;CAI Hu(Department of Integrated Chinese and Western Medicine,Cancer Hospital Affiliated to the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Hangzhou,Zhejiang 310022,China;不详)

机构地区：[1]中国科学院大学附属肿瘤医院(浙江省肿瘤医院)中西医结合科,浙江杭州310022 [2]中国科学院大学附属肿瘤医院(浙江省肿瘤医院)乳腺肿瘤内科 [3]浙江省中医药研究院药用资源研究中心,浙江杭州310000

出　　处：《中华全科医学》2022年第4期673-677,共5页Chinese Journal of General Practice

基　　金：浙江省中医药科技计划项目(2019ZB016)。

摘　　要：目的观察三黄三仙汤治疗脾肾亏虚型晚期乳腺癌患者癌因性疲乏(CRF)的疗效,为提高晚期乳腺癌患者的生存质量提供参考。方法采用随机数字表法将浙江省肿瘤医院2019年9月—2020年5月收治的80例脾肾亏虚型晚期乳腺癌患者分为对照组(40例)与观察组(40例),对照组给予姑息性化疗及相应的对症治疗;观察组在对照组的基础上联合中药“三黄三仙汤”治疗。对比分析2组治疗前后的生活质量(KPS)与中医临床症状评分、Piper疲乏量表评分,血清细胞因子与T淋巴细胞亚群各指标的变化,并记录不良反应情况。结果观察组治疗后中医临床症状评分、Piper疲乏量表评分、肿瘤坏死因子-α(TNF-α)和白细胞介素-4(IL-4)水平低于对照组,KPS评分、干扰素-γ(IFN-γ)和白细胞介素-2(IL-2)水平高于对照组(P<0.05)。观察组治疗后CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比值均优于对照组[(40.30±11.21)%vs.(35.06±9.37)%、(15.30±3.29)%vs.(17.17±3.53)%、(2.52±0.48)vs.(1.90±0.41),均P<0.05]。观察组不良反应发生率低于对照组(10.00%vs.27.50%,P<0.05)。结论三黄三仙汤能有效改善脾肾亏虚型晚期乳腺癌患者临床症状和生活质量,缓解患者癌因性疲乏症状,降低炎性因子水平,提高机体免疫能力,且安全有效。Objective To observe the effect of Sanhuang Sanxian Decoction on cancer-related fatigue(CRF)in patients with advanced breast cancer of spleen kidney deficiency type and to provide reference for improving the quality of life of patients with advanced breast cancer.Methods Eighty cases of advanced breast cancer patients of spleen kidney deficiency type in Zhejiang Cancer Hospital from September 2019 to May 2020 were randomly divided into the control group(40 cases)and observation group(40 cases).The control group was given palliative chemotherapy and symptomatic treatment,whereas the observation group was treated on the basis of the control group in combination with Sanhuang Sanxian Decoction.The Karnofsky performance scale(KPS),traditional Chinese medicine(TCM)clinical symptom score,Piper Fatigue Scale scores,serum cytokines and T lymphocyte subsets were compared before and after treatment,and the adverse reactions were recorded.Results After treatment,the TCM clinical symptom score,Piper Fatigue Scale score and tumour necrosis factor-αand interleukin(IL)-4 levels in the observation group were lower than those in the control group,whereas the KPS score and interferon-γand IL-2 levels in the observation group were higher than those in the control group(P<0.05).After treatment,the CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)ratio in the observation group were better than those in the control group(40.30±11.21)%vs.(35.06±9.37)%,(15.30±3.29)%vs.(17.17±3.53)%,(2.52±0.48)%vs.(1.90±0.41)%,respectively,all P<0.05.The incidence of adverse reactions in the observation group was lower than that in the control group(10.00%vs.27.50%,P<0.05).Conclusion Sanhuang Sanxian Decoction can effectively improve the clinical symptoms and quality of life of patients with advanced breast cancer of spleen kidney deficiency type,relieve CRF symptoms of patients with advanced breast cancer,reduce the level of inflammatory factors and improve the immune capacity of the body,and it is safe and effective.

关 键 词：三黄三仙汤 脾肾亏虚型 晚期乳腺癌 癌因性疲乏 疗效分析 

分 类 号：R737.9[医药卫生—肿瘤] R289.55[医药卫生—临床医学]