脑胶质瘤瘤周水肿区细胞外间隙改变及机制研究进展  

Recent advance in extracellular space changes and mechanisms in peritumor edema regions of brain gliomas

作　　者：马凯明 杨军 Ma Kaiming;Yang Jun(Department of Neurosurgery,Third Hospital,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院神经外科,北京100191

出　　处：《中华神经医学杂志》2022年第3期242-248,共7页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(82072774、81872051);中国博士后科学基金资助项目(2020M670064);北京大学临床科学家计划(BMU2019LCKXJ007)。

摘　　要：脑胶质瘤作为全球难治性肿瘤之一,近年来发病率逐年上升。瘤周水肿(PTBE)作为其主要临床特征之一,被证实是肿瘤浸润复发的主要来源区域。该区域细胞外间隙(ECS)组织间液引流分区系统及脑分区稳态存在明显改变,具体表现为ECS空间结构如体积分数及迂曲度、组织液引流、物质扩散及空间物理极性等方面的一系列变化,过程涉及多种分子生物学机制。本文重点从脑细胞微环境角度阐述脑胶质瘤PTBE区ECS具体改变及相关机制,以进一步探究该区域病理生理学改变,为基于ECS的脑胶质瘤诊疗新模式提供理论依据。As one of the refractory tumors in the world,brain glioma has increased incidence year by year in recent years.Peritumoral brain edema(PTBE),as one of the main clinical features of glioma,has proved to be the main source of recurrent tumor infiltrating area.There are significant changes in the interstitial fluid drainage partition system and the steady state of brain partitions in the extracellular space(ECS)of this area,embodied in ECS space structure(volume fraction and tortuosity),tissue fluid drainage,material diffusion,and space physical polarity.And this process involves a series of changes of molecular biology mechanisms.This paper focuses on the specific changes and related mechanisms of ECS in PTBE region of brain glioma from the perspective of the brain cells microenvironment,so as to further explore the pathophysiological changes in this region and provide theoretical basis for the new model of diagnosis and treatment of glioma based on ECS.

关 键 词：神经胶质瘤 瘤周水肿 细胞外间隙 肿瘤微环境 

分 类 号：R739.41[医药卫生—肿瘤]