规律运动对慢性创伤性脑病的改善效应及其机制  

Beneficial effects and mechanisms of regular exercise on chronic traumatic encephalopathy

作　　者：陈伟成 蔡凯宇 陈君涵 李昱静 吕雯奇 陈祥荣[1] Chen Weicheng;Cai Kaiyu;Chen Junhan;Li Yujing;Lyu Wenqi;Chen Xiangrong(Department of Neurosurgery,Second Clinical Medical College,Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学附属第二医院、第二临床医学院神经外科,泉州362000

出　　处：《中华神经医学杂志》2022年第3期305-311,共7页Chinese Journal of Neuromedicine

基　　金：福建省自然科学基金(2019J01168);泉州市高层次人才创新项目基金(2019C024R)。

摘　　要：规律运动时不恰当的反复打击头部,可引起轻度创伤性颅脑损伤(mTBI),产生持续的认知、行为和精神问题,最终导致慢性创伤性脑病(CTE)。但是,规律运动也能够作为一种抗大脑认知衰退的神经保护剂,对大脑的可塑性产生影响。规律运动能够通过减少异常蛋白堆积、促进神经发生及突触形成、增加突触可塑性和血管生成、改善微循环、抗微炎症和氧化应激、促进心理健康等方式提高大脑学习、记忆及认知功能,并显著地改善CTE的疾病过程。本文围绕CTE的病理改变及发生机制综述如下,探讨规律运动改善CTE后神经功能的机制,以期为CTE的康复治疗提供新思路。Physical exercise can accompany with risks,such as repeated blows to the head,causing mild traumatic brain injury(mTBI),and mTBI will cause continuous cognitive,behavioral and mental problems,bring neurodegeneration and ultimately lead to chronic traumatic encephalopathy(CTE).However,this regular exercise can also be used as a neuroprotective agent against cognitive decline in the brain and affect the plasticity of the brain.Regular exercise can improve the brain learning,memory,recognition and the disease process of CTE by reducing abnormal protein accumulation,promoting neurogenesis,synapse formation,increasing synaptic plasticity and angiogenesis,improving microcirculation,anti-microinflammation and oxidative stress,and promoting mental health.This review analyzes the pathological changes and mechanism of CTE and explore the mechanism of regular exercise in improving neurological function after CTE,so as to provide new ideas for CTE rehabilitation.

关 键 词：运动创伤 慢性创伤性脑病 神经变性 运动康复 规律运动 

分 类 号：R651.15[医药卫生—外科学]