最大圆感兴趣区勾画方法是可靠的颈神经根弥散张量成像测量方法  

Establishment of diffusion tensor imaging in cervical nerve root ROI outline method and analysis of clinical relevance

作　　者：伍鹏欢 严德星 黄成燕 吴强 李文虎 袁艾东 史本超[4] WU Penghuan;YAN Dexing;HUANG Chengyan;Wu Qiang;LI Wenhu;YUAN Aidong;SHI Benchao(Department of Joint Orthopeadics and Sports Medicine,The First People's Hospital of Shaoguan(Shaoguan Hospital of Southern Medical University),Shaoguan 512000,China;Department of Radiology,The First People's Hospital of Shaoguan(Shaoguan Hospital of Southern Medical University),Shaoguan 512000,China;Department of Radiology,Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China;Department of Spine Surgery,Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China)

机构地区：[1]韶关市第一人民医院(南方医科大学附属韶关医院)关节运医科,广东韶关512000 [2]韶关市第一人民医院(南方医科大学附属韶关医院)影像中心,广东韶关512000 [3]南方医科大学珠江医院影像中心,广东广州510280 [4]南方医科大学珠江医院脊柱外科,广东广州510280

出　　处：《分子影像学杂志》2022年第2期167-174,共8页Journal of Molecular Imaging

基　　金：国家自然科学青年基金(31701048);韶关市科技计划项目(2019sn029);韶关市卫生健康科研项目(Y20070)。

摘　　要：目的 建立可靠的颈神经根感兴趣区(ROI)勾画方法,并对其临床相关性进行验证。方法 选取20例健康志愿者和20例单节段神经型颈椎病患者,由2名影像科医师应用4种ROI勾画方法,分别测量健康志愿者双侧颈5~8神经根的各向异性分数(FA)值和表观弥散系数(ADC)值,以及患者的患侧病变节段和健侧相应神经根FA值和ADC值,确定一致性最好的颈神经根ROI勾画方法,同时记录每位受试者的年龄、性别、BMI以及患者的VAS评分和ISNCSCI评分,然后采用最佳方法测量得到的弥散张量成像值,分析其临床特征相关性。结果 最大圆法的一致性最佳;健康者颈神经根FA值与ADC值与患者健侧颈神经根FA值和ADC值差异无统计学意义(P>0.05),与患侧颈神经根FA值和ADC值,差异有统计学意义(P<0.05);患者健康侧FA值和ADC值与患侧差异有统计学意义(P<0.05);对于健康志愿者,测得FA值与ADC值,与年龄有相关性(P<0.05),年龄越大,FA值越小,ADC值越大,但是与BMI无相关性;对于患者,VAS评分与患侧ADC值呈正相关(P<0.05),与患侧FA/患侧ADC比值呈负相关(P<0.05),ISNCSCI评分与患侧FA值呈正相关(P<0.05)。结论 最大圆ROI勾画方法是可靠的颈神经根弥散张量成像测量方法;患者神经根性痛越明显,则ADC值越大,FA/患侧ADC比值越小;颈椎神经功能越好,则FA值越大。Objective To establish a reliable method for the region-of-interest(ROI) mapping of cervical nerve roots and to verify its clinical relevance. Methods Twenty healthy volunteers and 20 patients with single-segment neurological cervical spondylopathy were selected. Four ROI mapping methods were applied by two imaging physicians to measure the fractional anisotropy(FA) and apparent diffusion coefficient(ADC) values of bilateral cervical 5-8 nerve roots in healthy volunteers as well as the FA and ADC values of the corresponding nerve roots on the affected lesioned segment and the healthy side of the patient to determine the best consistent method for the ROI mapping of the cervical nerve roots, while recording each subject’s age, gender, BMI, the patient’s VAS score and ISNCSCI score, and then analyzed the clinical characteristic correlations using the best method to measure the obtained diffusion tensor imaging values. Results The maximum circle method had the best consistency. The difference between FA and ADC values of the cervical nerve roots in healthy patients had no statistical significance compared with those of the healthy side of the patients(P>0.05), but had statistical significance compared with those of the affected side. The difference between FA and ADC values on the healthy side of patients and on the affected side was statistically significant(P<0.05);measured FA and ADC values were correlated with age(P<0.05), and the older the age, the smaller the FA value and the larger the ADC value, but there was no correlation with BMI. In terms of patients, VAS scores were positively correlated with ADC values on the affected side(P<0.05) and negatively correlated with FA/ADC ratio on the affected side(P<0.05), and ISNCSCI scores were positively correlated with FA values(P<0.05). Conclusion The maximum circle ROI mapping method is a reliable method for diffusion tensor imaging measuring cervical nerve roots. The more obvious the radicular pain, the greater the ADC value and the smaller affected side FA/ADC

关 键 词：磁共振 弥散张量成像 感兴趣区域 神经根型颈椎病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.55[医药卫生—诊断学]