FN1(-)及Vimentin(+)与早期乳腺癌非前哨淋巴结转移的关系  

Analysis of Relationship Between FN1(-)and Vimentin(+)and No-sentinel Lymph Node Metastasis in Early Breast Cancer

作　　者：徐胜昔[1] 李森 石颖芳 王恒丹 李梦琴 汪志春[1] XU Shengxi;LI Sen;SHI Yinfang(Jiujiang First People's Hospital,Jiujiang,332000)

机构地区：[1]江西省九江市第一人民医院,332000

出　　处：《实用癌症杂志》2022年第4期577-582,共6页The Practical Journal of Cancer

基　　金：江西省卫生健康委科技计划(编号:20204225)。

摘　　要：目的探讨早期乳腺癌非前哨淋巴结转移的独立风险因素。方法收集111例早期乳腺癌患者的临床病理资料,临床腋窝表现为阴性,成功行前哨淋巴结活检,显示为阳性,随后行同侧腋窝淋巴结清扫,应用统计学软件对相关因素进行分析。将单因素分析有统计学显著意义的因素纳入logistic多因素回归分析,找出非前哨淋巴结转移的独立风险因素。结果在单因素分析中,患者年龄、原发肿瘤大小、与淋巴管血管侵犯状况、Ki-67状态、SLN转移阳性数(SLN+)、SLN转移阴性数(SLN-)、SLN转移阳性数占SLN总数的比例(SLN+/SLN)、纤维连接蛋白1(FN1)表达以及波形蛋白(Vimentin)表达等因素在非前哨淋巴结阳性组与阴性组间有统计学差异,对以上因素采用二元logistic回归分析,结果显示原发肿瘤大小,纤维连接蛋白1(FN1)表达水平以及波形蛋白(Vimentin)表达水平,两组具有统计学上差异(P<0.05)。结论原发肿瘤大小,FN1(-)以及Vimentin(+)是早期乳腺癌非前哨淋巴结转移的独立风险因素。Objective To study the independent risk factors of early breast cancer with non-sentinel lymph node metastasis.Methods The clinicopathological data of 111 patients with early breast cancer who were clinically negative for axillary lymph node biopsy and positive for successful sentinel lymph node biopsy were retrospectively collected.Statistical software was used to analyze the related factors,Factors with statistical significance in univariate analysis were included in logistic multifactor regression analysis to identify independent risk factors for non-sentinel lymph node metastasis.Results In univariate analysis,age,primary tumor size,and lymphatic vascular invasion status,Ki-67 status,positive number of SLN metastasis(SLN+),negative number of SLN metastasis(SLN-),proportion of positive number of SLN metastasis to total number of SLN(SLN+/SLN),expression of fibronectin 1(FN1)and Vimentin(+)showed statistical differences between the non-sentinel lymph node positive group and the negative group.Binary logistic regression analysis of the above factors showed that the size of the primary tumor,the expression of fibronectin 1(FN1)and Vimentin(+)were significantly different(P<0.05).Conclusion Primary tumor size,FN1(-),and Vimentin(+)are independent risk factors for non-sentinel lymph node metastasis in early breast cancer.

关 键 词：乳腺癌 非前哨淋巴结 FN1 VIMENTIN 独立风险因素 

分 类 号：R737.9[医药卫生—肿瘤]