替牙期单侧完全性唇腭裂患者上颌骨复合体三维有限元模型的建立  

Establishment of three-dimensional finite element model of maxillary complex of unilateral complete cleft lip and palate during dentition stage

作　　者：杨彩秀 范存晖[1] 许涛[1] 房晓旭 王文惠 郑英泽 刘晓洁[1] YANG Cai-xiu;FAN Cun-hui;XU Tao;FANG Xiao-xu;WANG Wen-hui;ZHENG Ying-ze;LIU Xiao-jie(Stomatology Center of Affiliated Hospital of Qingdao University,School of Stomatology of Qingdao University,Qingdao Stomatological Digital Medicine and 3D Printing Engineering Laboratory,Qingdao 266003,Shandong,China)

机构地区：[1]青岛大学附属医院口腔医学中心,青岛大学口腔医学院,青岛市口腔数字医学与3D打印工程实验室,山东青岛266003

出　　处：《生物医学工程与临床》2022年第2期143-149,共7页Biomedical Engineering and Clinical Medicine

基　　金：青岛大学附属医院临床医学+X基金支持项目。

摘　　要：目的通过建立单侧完全性唇腭裂(UCLP)患者上颌骨复合体三维(3D)有限元模型,为后期利用3D有限元分析方法来研究该患者牙颌面畸形形成的机制及治疗提供条件。方法选择1例8岁男性替牙期UCLP患者,提取锥形束CT(CBCT)图像,依次在Mimics 15.0医学图像处理软件中提取轮廓和截取范围、Geomagic Studio 10逆向工程软件中优化平滑处理、Hypermesh建模划分网格软件中划分网格和格式转换,最后导入Abaqus 6.14有限元建模与分析软件中。通过对上颌骨复合体3D有限元模型导入Abaqus 6.14有限元建模与分析软件中进行仿真计算进行验证。结果上颌骨轮廓的提取是根据骨组织CT的灰度值,阈值范围为226~1222 Hu,自动生成蒙板(Mask);利用选择性编辑(Edit masks)工具中Draw、Erase、Threshold等功能去除毛刺,填补空洞;经计算(calculate 3D from mask)生成上颌骨复合体3D几何模型。然后得到STP格式的几何模型,最后建立了包含上颌骨、颧骨、部分眼眶、蝶骨及部分颅骨的UCLP上颌骨复合体3D有限元模型,节点数为205415,单元数为127181。Abaqus 6.14有限元建模与分析软件中仿真分析,矢状向、水平向位移与临床相符。结论应用CBCT扫描和Mimics、Geomagic、Hypermesh、Abaqus软件相结合的方法,建立的模型细致逼真,方法简便高效。Objective To establish the three-dimensional(3D)finite element model of maxillary complex of patients with unilateral complete cleft lip and palate(UCLP),and provide conditions for later study of formation mechanism and treatment in dental and maxillofacial deformities by 3D finite element analysis(FEA)method.Methods One 8-year-old male UCLP patient was enrolled,cone beam CT(CBCT)images were extracted,the contours and intercepting range were extracted in Mimics15.0 medical image procassing software,optimized smoothing was carried out by Geomagic Studio 10 reverse engineering software,meshing and format conversion was completed by Hypermesh modeling and meshing software,and the data was imported into Abaqus 6.14 fintite element modeling and analysis software.The 3D finite element model of the maxillary complex was imported into Abaqus 6.14 finite element modeling and analysis software for simulation calculation and verification.Results The contour of maxillary bone was extracted,and mask(Mask)was automatically generated according to gray value of bone tissue CT,with the threshold range of 226-1222 Hu;the functions of Draw,Erase,Threshold in Edit masks were used to remove burrs and fill holes;and 3D geometric model of maxillary complex was generated and calculated(calculate 3D from mask).Geometric model in STP format was obtained.Finally,the 3D finite element model of UCLP maxillary complex including maxilla,cheekbones,part of orbit,sphenoid bone and part of skull were established.The number of nodes was 205415 and the number of elements was 127181.The Abaqus 6.14 finite element modeling and analysis software simulation analysis results showed that the sagittal and horizontal displacements were consistent with the clinical results.Conclusion It is demonstrated that established model by method of CBCT scanning combined with Mimics,Geomagic,Hypermesh and Abaqus software is detailed,realistic,simple and efficient.

关 键 词：腭裂 上颌骨复合体 几何模型 三维有限元模型 

分 类 号：R782.2[医药卫生—口腔医学] R318.01[医药卫生—临床医学]