Sesquiterpenoids from the leaves of Sarcandra glabra  

作　　者：WANG Yong-Yue LI Qiu-Rong CHI Jun LI Ji-Xin KONG Ling-Yi LUO Jun 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2022年第3期215-220,共6页中国天然药物（英文版）

基　　金：supported in part by the National Natural Science Foundation of China(No.320703S9);the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China(No.B18056);the Drug Innovation Major Project(No.2018ZX09735002-003).

摘　　要：Sarglanoids A-F,six new sesquiterpenoids belonging to eudesmane(1-5)and eremophilane(6)types,were isolated from the leaves of Sarcandra glabra,a famous traditional Chinese medicine(TCM).Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism(ECD)calculations.Compounds 1-2 were rare N-containing eudesmane-type sesquiterpenoids.Compound 3 exhibited inhibitory activity against nitric oxide(NO)production in lipopolysaccharides(LPS)-induced RAW 264.7 cells with IC_(50) values at 20.00±1.30μmol·L^(-1).These findings provide scientific evidence for sesquiterpenoids as the material foundation of S.glabra.

关 键 词：Sarcandra glabra SESQUITERPENOIDS N-containing sesquiterpenoids ANTI-INFLAMMATORY 

分 类 号：R284.1[医药卫生—中药学]