40岁以上正常人的黄斑血流密度和灌注密度改变  

Age-related changes in the macular vessel density and perfusion density of normal subjects with age beyond 40 years

作　　者：霍妍佼 郭彦 杨丽红 魏文斌 Huo Yanjiao;Guo Yan;Yang Lihong;Wei Wenbin(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,100730

出　　处：《眼科》2022年第2期125-129,共5页Ophthalmology in China

基　　金：北京市属医院科研培育计划(PX2020010)。

摘　　要：目的比较相干光断层扫描血管成像(OCTA)测得≥40岁和18~39岁正常人黄斑血流密度和灌注密度的差异。设计横断面研究。研究对象2020年10-12月北京同仁医院健康体检者142例(142眼)。其中男性76例(76眼)。平均年龄(45.50±12.65)岁。方法受试者分为18~39岁组和≥40岁组。行视力、等效球镜(SE)、眼压、眼底照相、裂隙灯显微镜、黄斑区6 mm×6 mm OCTA检查。取右眼数据纳入分析。年龄对血流密度、灌注密度和黄斑无血管区(FAZ)面积的影响采用简单线性回归分析。主要指标黄斑血流密度、灌注密度和FAZ面积。结果≥40岁组黄斑区总体血流密度为(17.49±1.15)mm^(-1),显著低于18~39岁组(17.88±9.76)mm^(-1)(P=0.037)。≥40岁组黄斑区外环血流密度为(17.83±1.12)mm^(-1),显著低于18~39岁组(18.24±1.00)mm^(-1)(P=0.027)。其他黄斑区血流密度参数、血流灌注各参数和FAZ面积在两组间无统计学差异(P均>0.05)。简单线性回归分析显示,年龄每增加1岁黄斑总体血流密度减少0.02 mm^(-1)(t=-2.34,P=0.021),黄斑区外环血流密度减少0.02 mm^(-1)(t=-2.42,P=0.017)。年龄对黄斑区其他血流密度参数、灌注密度各参数和FAZ面积均无显著影响(P均>0.05)。结论正常成年人黄斑区血流密度随年龄增长而下降,≥40岁人群黄斑区血流密度较18~39岁者明显降低。Objective To compare age-related changes of the macular vessel density and perfusion density with optical coherence tomography angiography(OCTA)measurements in normal adults between under and over beyond 40 years old.Design Cross-sectional study.Participants One hundred and forty-two subjects(76 males,aged 45.50±12.65 years)were recruited from October 2020 to December 2020 in the Beijing Tongren Health Center.Methods All subjects were divided into 18-39 years old group and≥40 years old group.Visual acuity,spherical equivalent(SE),intraocular pressure,slit lamp microscope,color fundus photography and 6 mm×6 mm macular OCTA were conducted for all eyes.The data of right eye was analyzed.Simple regression analysis determined the association between age vs.macular vessel density,perfusion density and area of FAZ.Main Outcome Measures Macular vessel density,perfusion density and the area of FAZ.Results The macular of total vessel density was(17.49±1.15)mm^(-1) in age beyond 40 years group,which was significantly lower than that of the age under 40 years(17.88±9.76)mm^(-1)(P=0.037).The outer-ring of macular vessel density in age beyond 40 years group was(17.83±1.12)mm^(-1),which was significantly lower than that of the age under 40 years(18.24±1.00)mm^(-1).There were no significant differences in other macular vessel density,perfusion density and the area of FAZ between the two groups(all P>0.05).The macular total vessel density decreased by 0.02 mm^(-1)(t=-2.34,P=0.021)per year with increasing age.The outer-ring of macular vessel density decreased by 0.02 mm^(-1)(t=-2.42,P=0.017)per year with increasing age.Age have no impact on other macular vessel density parameters,perfusion density and the area of FAZ(all P>0.05).Conclusion Macular vessel density shows age-related decrease with significant drop in the 4th decade.These factors should be considered carefully if using OCTA to measure macular vessel flow.

关 键 词：相干光断层扫描血管成像 年龄 

分 类 号：R774.5[医药卫生—眼科]