Network pharmacology-based virtual screening of the active volatile oil ingredients of Litsea lancilimba Merr. and their potential targets for treating liver cancer  

作　　者：Yijie Zhang Ming Bai Weiyu Zhou Xiaoxiao Huang Shaojiang Song 

机构地区：[1]Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development,Liaoning Province,School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Asian Journal of Traditional Medicines》2022年第2期47-50,共4页亚洲传统医药（英文）

摘　　要：Liver cancer remains the dominant cause of cancer-related death, despite the advent of targeted therapies and immunotherapies. Therefore, there is an urgent need to explore novel chemotherapeutic agents and effective strategies against the cancer. There are a lot of monoterpenes and sesquiterpenoids in L. lancilimba. It has been reported that monoterpenes and sesquiterpenoids have certain anti-tumor effects. Literature investigation has also shown that Litsea lancilimba Merr. has antibacterial and antiviral effects. In this experiment, we used network pharmacology to screen the active compounds from L. lancilimba and their potential targets for treating liver cancer. Four active volatile oil ingredients and four potential targets have been identified. Our results provide the lead compound from L. lancilimba in the treatment of liver cancer.

关 键 词：Litsea lancilimba Merr. network pharmacology liver cancer 

分 类 号：R73[医药卫生—肿瘤]