Polymeric microneedle-mediated sustained release systems: Design strategies and promising applications for drug delivery  

作　　者：Li Yang Yao Yang Hongzhong Chen Lin Mei Xiaowei Zeng 

机构地区：[1]Institute of Pharmaceutics,School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen 518107,China [2]Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2022年第1期70-86,共17页亚洲药物制剂科学（英文）

基　　金：financial support from the National Natural Science Foundation of China (32071342 and 31922042);Guangdong Special Support Program (2019TQ05Y209);the Fundamental Research Funds for the Central Universities (19ykzd31)。

摘　　要：Parenteral sustained release drug formulations, acting as preferable platforms for longterm exposure therapy, have been wildly used in clinical practice. However, most of these delivery systems must be given by hypodermic injection. Therefore, issues including needle-phobic, needle-stick injuries and inappropriate reuse of needles would hamper the further applications of these delivery platforms. Microneedles (MNs) as a potential alternative system for hypodermic needles can benefit from minimally invasive and self-administration. Recently, polymeric microneedle-mediated sustained release systems (MN@SRS) have opened up a new way for treatment of many diseases. Here, we reviewed the recent researches in MN@SRS for transdermal delivery, and summed up its typical design strategies and applications in various diseases therapy, particularly focusing on the applications in contraception, infection, cancer, diabetes, and subcutaneous disease. An overview of the present clinical translation difficulties and future outlook of MN@SRS was also provided.

关 键 词：Transdermal drug delivery MICRONEEDLES Sustained release Long-term exposure therapy 

分 类 号：R943[医药卫生—药剂学]