酪酸梭菌活菌散对新生儿肺炎抗生素相关性腹泻的疗效分析  

Efficacy analysis of Clostridium butyricum powder for antibiotic-associated diarrhea in neonatal pneumonia

作　　者：张峰华[1] 张碧清[1] 吴州丽[1] 刘远威 张晔 段晨敏 ZHANG Feng-hua;ZHANG Bi-qing;WU Zhou-li;LIU Yuan-wei;ZHANG Ye;DUAN Chen-min(Chenzhou First People’s Hospital,Hunan423000,China)

机构地区：[1]郴州市第一人民医院,湖南423000

出　　处：《医学动物防制》2022年第3期258-261,共4页Journal of Medical Pest Control

摘　　要：目的分析酪酸梭菌活菌散对新生儿肺炎抗生素相关性腹泻(antibiotic-associated diarrhea, AAD)的疗效。方法选取2018年1月—2019年7月某院收治的76例肺炎AAD新生儿病例,随机分为对照组和观察组,每组38例,2组均予以常规治疗,其中对照组给予蒙脱石散+去乳糖奶粉喂养,观察组给予蒙脱石散+去乳糖奶粉喂养+酪酸梭菌活菌。比较2组止泻时间、临床疗效、治疗前后肠屏障功能指标[血清细菌内毒素(serum bacterial endotoxin, BT)、二胺氧化酶(diamine oxidase, DAO)、D-乳酸(D-lactate acid, D-LC)水平]、不良反应发生情况。结果观察组止泻时间短于对照组,差异有统计学意义(t=9.033,P<0.05);2组临床疗效等级分布差异有统计学意义(Z=8.496,P<0.05),观察组总有效率高于对照组,差异有统计学意义(χ^(2)=7.710,P<0.05);治疗后2组血清BT、DAO和D-LC水平均下降(观察组:t=36.875、20.959、28.476,对照组:t=32.741、16.854、25.425,P<0.05),且观察组的各项数值均较对照组更低(t=12.082、4.745、8.310,P<0.05),差异均有统计学意义;2组不良反应总发生率差异无统计学意义(t=0.671,P>0.05)。结论酪酸梭菌活菌散治疗新生儿肺炎AAD可缩短止泻时间,提高临床疗效,改善肠屏障功能,且安全性好。Objective To analyze the efficacy of Clostridium butyricum powder on antibiotic-associated diarrhea(AAD) in neonates with pneumonia.Methods A total of 76 cases of AAD from neonates with pneumonia admitted to a hospital from January 2018 to July 2019 were randomly selected, and divided into two equal groups.The neonates in both cases were treated with conventional therapies, the neonates in the control group were treated with montmorillonite powder+lactose-free milk powder feeding, while the neonates in the observation group with montmorillonite powder+lactose free milk powder feeding+Clostridium butyricum powder.The diarrhea stopping time, clinical efficacy, the level of intestinal barrier function indexes[serum bacterial endotoxin(BT),diamine oxidase(DAO),D-lactate acid(D-LC) levels]before and after treatment and occurrence conditions of adverse reactions were compared between groups.Results The diarrhea stopping time in the observation group was lower than that in the control group, and the difference was statistically significant(t=9.033,P<0.05).The difference in the clinical efficacy grade distribution between two groups(Z=8.496,P<0.05) was statistically significant, and the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(χ^(2)=7.710,P<0.05).The level of serum BT,DAO and D-LC in groups decreased on treatment(the observation group: t=36.875,20.959,28.476,the control group: t=32.741,16.854,25.425,P<0.05),the numerical values of the observation group were lower(t=12.082,4.745,8.310,P<0.05),and the differences were statistically significant.There was no significant difference in the incidence of adverse reactions between groups(t=0.671,P>0.05).Conclusion Clostridium butyricum powder is capable of shortening the diarrhea stopping time, enhancing the clinical efficacy and improving the intestinal barrier function with great safe.

关 键 词：酪酸梭菌活菌散 新生儿肺炎 抗生素相关性腹泻 疗效 细菌内毒素 二胺氧化酶 D-乳酸 

分 类 号：R722.13[医药卫生—儿科]