乳腺癌组织中NM23及上皮钙黏素的表达与新辅助化疗效果的关系  

Relationship between the expression of NM23 and E-cadherin and the efficacy of neoadjuvant chemotherapy in breast cancer

作　　者：杨磊[1] 杨宏伟[1] 陈茂山[1] 牟德武 程晓明 YANG Lei;YANG Hongwei;CHEN Maoshan;MU Dewu;CHENG Xiaoming(Department of Breast and Thyroid Surgery,Suining Central Hospital,Sichuan Province,Suining 629000,China;Department of Thyroid and Breast Surgery,Affiliated Hospital of Zunyi Medical University,Guizhou Province,Zunyi 563000,China)

机构地区：[1]四川省遂宁市中心医院乳腺甲状腺外科,四川遂宁629000 [2]遵义医科大学附属医院甲状腺乳腺外科,贵州遵义563000

出　　处：《中国医药导报》2022年第8期93-96,共4页China Medical Herald

基　　金：重庆市科学技术局超声医学工程国家重点实验室面上项目(2020KFKT011)。

摘　　要：目的探讨乳腺癌组织中NM23和上皮钙黏素的表达与新辅助化疗(NCT)效果的关系。方法收集遵义医科大学附属医院甲状腺乳腺外科2014年10月至2017年10月收治的浸润性乳腺癌并接受NCT患者87例的临床资料。根据NCT效果将其分为有效组(63例)和无效组(24例)。采用免疫组化方法检测87例浸润性乳腺癌患者NCT前癌组织中NM23和上皮钙黏素的表达,分析NM23和上皮钙黏素的表达与NCT效果的关系。结果无效组的NM23阳性、TNM分期为Ⅲ期、人表皮生长因子受体-2阳性占比均低于有效组,上皮钙黏素阳性占比高于有效组,差异有统计学意义(P<0.05)。多因素分析结果显示,上皮钙黏素表达阳性是乳腺癌NCT无效的独立危险因素(OR>1,P<0.05),NM23表达阳性及TNM分期为Ⅲ期是其保护因素(OR<1,P<0.05)。结论乳腺癌组织的NM23和上皮钙黏素表达均与乳腺癌NCT效果存在显著相关性,对评估乳腺癌患者NCT后的效果有一定的参考价值。Objective To investigate the relationship between the expression of NM23 and E-cadherin and the efficacy of neoadjuvant chemotherapy(NCT)in breast cancer.Methods The clinical data of 87 patients with invasive breast cancer who received NCT were collected from Department of Thyroid and Breast Surgery,Affiliated Hospital of Zunyi Medical University from October 2014 to October 2017.According to the effect of NCT,they were divided into effective group(63 cases)and ineffective group(24 cases).The expression of NM23 and E-cadherin in NCT precancerous tissues of 87 patients with invasive breast cancer was detected by immunohistochemical method,and the relationship between the expression of NM23 and E-cadherin and the effect of NCT was analyzed.Results The proportion of NM23 positive,TNM stageⅢ,and human epidermal growth factor receptor-2 positive in ineffective group were lower than those in effective group,and the proportion of E-cadherin positive was higher than that in effective group,the differences were statistically significant(P<0.05).Multivariate analysis showed that positive E-cadherin expression was an independent risk factor for NCT inefficacy in breast cancer(OR>1,P<0.05),while positive NM23 expression and TNM stageⅢwere protective factors(OR<1,P<0.05).Conclusion The expression levels of NM23 and E-cadherin in breast cancer tissues are significantly correlated with the effect of NCT in breast cancer,which has certain reference value for evaluating the effect of breast cancer patients after NCT.

关 键 词：乳腺癌 NM23 上皮钙黏素 新辅助化疗 相关性 

分 类 号：R737.9[医药卫生—肿瘤]