保乳手术治疗早期三阴乳腺癌患者的效果及安全性  

Efficacy and security of breast conserving surgery in the treatment of early triple negative breast cancer patients

作　　者：王晓东[1] 陈大鹏[1] 彭永强[1] WANG Xiaodong;CHEN Dapeng;PENG Yongqiang(Department of Breast Surgery,Bozhou People’s Hospital,Anhui Province,Bozhou 236800,China)

机构地区：[1]安徽省亳州市人民医院乳腺外科,安徽亳州236800

出　　处：《中国医药导报》2022年第8期109-112,共4页China Medical Herald

摘　　要：目的探讨保乳手术治疗早期三阴乳腺癌(TNBC)患者的临床效果及安全性。方法选取2018年1月至2021年2月安徽省亳州市人民医院收治的早期TNBC患者110例为研究对象。按照随机数字表法,将其分为对照组和观察组,各55例。对照组给予乳腺癌改良根治术治疗,观察组给予保乳手术治疗。比较两组术中出血量、手术时间、术后引流时间及术后并发症的发生情况,术后随访3个月观察有无局部复发及远处转移情况,比较手术前后生活质量评分。结果观察组术中出血量少于对照组,手术时间、术后引流时间短于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。两组局部复发率、远处转移率比较,差异无统计学意义(P>0.05)。手术前,两组生活质量评分比较,差异无统计学意义(P>0.05);手术后,两组生活质量评分高于手术前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论早期TNBC患者经保乳手术治疗效果显著,恢复较快,安全性高,值得临床推广应用。Objective To investigatethe clinical efficacy and security of breast conserving surgery in the treatment of early triple negative breast cancer(TNBC)patients.Methods A total of 110 early TNBC patients admitted to Bozhou People’s Hospital,Anhui Province from January 2018 to February 2021 were selected as study objects.According to the random number table method,they were divided into control group and observation group,with 55 cases in each group.The control group was treated with modified radical mastectomy,and observation group was treated with breast conserving surgery.The amount of intraoperative blood loss,operation time,postoperative drainage time,and the incidence of postoperative complications were compared between two groups,local recurrence and distant metastasis were observed during postoperative follow-up for three months,and the quality of life scores before and after operation were compared.Results The amount of intraoperative blood loss of observation group was lower than that of control group,and operation time and postoperative drainage time were shorter than those of control group,and the differences were statistically significant(P<0.05).The total incidence of complications in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).There were no significant differences in local recurrence rate and distant metastasis rate between two groups(P>0.05).Before operation,there were no significant differences in quality of life scores between two groups(P>0.05);after operation,the quality of life scores of two groups were higher than those before operation,and observation group was higher than control group,and the differences were statistically significant(P<0.05).Conclusion Breast conserving surgery for early TNBC patients has significant effect,rapid recovery and high safety,which is worthy of clinical application.

关 键 词：保乳手术 三阴乳腺癌 临床疗效 远期疗效 安全性 

分 类 号：R737.9[医药卫生—肿瘤]