阿片类物质成瘾相关情况的研究进展  

Research progress in opioid addiction related conditions

作　　者：刘鹏 李萍 杜洪霞 魏明 LIU Peng;LI Ping;DU Hongxia;WEI Ming(Department of Pharmacology and Toxicology,Institute of Basic Medicine Science,Xi’an Medical University,Shaanxi Province,Xi’an 710021,China)

机构地区：[1]西安医学院基础医学部药理学与毒理学教研室,陕西西安710021

出　　处：《中国医药导报》2022年第7期55-59,共5页China Medical Herald

基　　金：陕西省高校科协青年人才托举计划项目(20200315);西安医学院博士科研启动基金项目(2020DOC15)。

摘　　要：药物成瘾为一种复发性、慢性的脑疾病,对于药物成瘾的生物学机制认知已经成为了开发有针对性及有效性治疗手段的迫切要求。阿片类物质在其应用过程中不可避免地会产生成瘾性,这是其主要局限性之一。本文从阿片物质分类、阿片受体、滥用的现状及治疗手段、成瘾的遗传易感性、吗啡成瘾相关的重要脑区及神经环路,五个方面对阿片类物质成瘾进行概述并归纳整理现有研究的新发现,以期帮助研究人员对阿片类物质成瘾形成初步、整体的认识。Drug addiction is a kind of recurrent and chronic brain disease,and the recognition of the biological mechanism of drug addiction has become an urgent requirement to develop targeted and effective treatment methods.One of the major limitations of opioids is that opioids are inevitably addictive in their application.This article provides an overview of opioid addiction and summarizes the new findings of existing researches from five aspects:opioid classification,opioid receptors,current status and treatment of drug abuse,genetic susceptibility to addiction,important brain regions and neural circuits related to Morphine addiction,in order to help researchers to form a preliminary,overall understanding of opioid addiction.

关 键 词：阿片类物质 药物成瘾 遗传易感性 成瘾神经环路 

分 类 号：R749.6[医药卫生—神经病学与精神病学]