极高危绒毛膜癌伴高钙血症一例并文献复习  

Choriocarcinoma of Extremely High Risk with Hypercalcemia:A Case Report and Literature Review

作　　者：程喆 刘玉珍[2] 张海凤[2] CHENG Zhe;LIU Yu-zhen;ZHANG Hai-feng(Weifang Medical University,Weifang 261000,Shandong Province,China;Affiliated Hospital of Weifang Medical University,Weifang 261000,Shandong Province,China)

机构地区：[1]潍坊医学院,261000 [2]潍坊医学院附属医院

出　　处：《国际妇产科学杂志》2022年第2期238-240,共3页Journal of International Obstetrics and Gynecology

摘　　要：绒毛膜癌是死亡率极高的一种妇科肿瘤,随着化疗药物在临床的合理应用,该病也获得了较满意的疗效。恶性肿瘤常伴有高钙血症的发生,但高钙血症在绒毛膜癌中的发生率极低。报告1例血人绒毛膜促性腺激素β亚单位(β-hCG)高达1400588.00 IU/L,且以高钙血症为突出表现的极高危绒毛膜癌(Ⅱ,13)患者的诊断与治疗过程,以降钙、化疗及手术相结合为主的方式对患者进行了成功救治。β-hCG降至正常范围后,患者拒绝行巩固化疗,密切随访6个月,未见病情反弹。通过对本病例的分析为绒毛膜癌的临床表现、诊断、治疗及随访提供一种新的思路。Choriocarcinoma is a kind of gynecological tumor with extremely high mortality.With the rational application of chemotherapeutic drugs,choriocarcinoma can also get a satisfactory curative effect.Hypercalcemia is often associated with malignant tumors,but the incidence of hypercalcemia in choriocarcinoma is very low.We report a case of diagnosis and treatment of extremely high-risk choriocarcinoma(Ⅱ,13)characterized byβ-hCG up to 1400588.00 IU/L and hypercalcemia in blood.During the process of diagnosis and treatment,the patients were treated successfully by a combination of treatment about calcium reduction,chemotherapy and surgery.Afterβ-hCG decreased to the normal range,the patient refused to receive consolidation chemotherapy.After 6 months of close follow-up,we don′t observe the disease bounces back.This case provides a new thinking for the clinical manifestation,diagnosis,treatment and follow-up of choriocarcinoma.

关 键 词：绒毛膜癌 绒毛膜癌 非妊娠期 绒毛膜促性腺激素 β亚单位 人 高钙血症 抗肿瘤联合化疗方案 

分 类 号：R737.3[医药卫生—肿瘤]