硒与桥本甲状腺炎的相关性研究进展  

Research progress on the relationship between selenium and Hashimoto thyroiditis

作　　者：耿文倩 祁烁[1] 陈晓珩[1] 李哲[1] 李会龙[1] 刘美君 葛亚雪 丁治国[1] GENG Wenqian;QI Shuo;CHEN Xiaoheng;LI Zhe;LI Huilong;LIU Meijun;GE Yaxue;DING Zhiguo(Department of Thyroid,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院甲状腺病科,北京100700

出　　处：《中国医药导报》2022年第10期55-58,共4页China Medical Herald

基　　金：北京市中医管理局北京中医药“薪火传承3+3工程”建设项目(2016-SZ-C-61)。

摘　　要：近年来,桥本甲状腺炎(HT)的发病率逐年增高,硒作为一种必需的微量元素,与HT的发病机制有关。大多数研究将硒的免疫调节作用归因于其抗氧化特性。谷胱甘肽过氧化物酶系,硫氧还蛋白还原酶系和碘甲状腺素脱碘酶系共同构成硒蛋白家族,不仅直接参与甲状腺激素的合成,更能够调节甲状腺内部氧化还原状态,保护甲状腺免受氧化应激的损伤。目前已经有许多国内外研究支持硒对降低HT患者甲状腺自身抗体滴度有效,但仍缺乏十分有力的证据证实硒对治疗HT明确有效。补硒治疗是否能成为HT的标准治疗手段仍有待商榷。In recent years,the incidence of Hashimoto thyroiditis(HT)has been increasing year by year.Selenium,as an essential trace element,is related to the pathogenesis of HT.Most studies attribute the immunomodulatory effects of selenium to its antioxidant properties.Glutathione peroxidase system,thioredoxin reductase system and iodothyronine deiodase system together constitute the selenoprotein family,which not only directly participate in the synthesis of thyroid hormones,but also regulate the internal REDOX state of the thyroid gland and protect the thyroid gland from oxidative stress damage.At present,many studies have supported the efficacy of selenium in reducing thyroid auto-antibody titers in HT patients,but there is still a lack of sufficient evidence to confirm the clear efficacy of selenium in the treating of HT.Whether selenium supplementation can become the standard treatment for HT remains to be discussed.

关 键 词：硒 硒蛋白 自身免疫性甲状腺炎 桥本甲状腺炎 补硒疗法 

分 类 号：R581.4[医药卫生—内分泌]