经支气管镜下冷热联合消融技术治疗肺癌引发气道狭窄的临床效果  

Clinical effect of transbronchoscopic cryotherapy combined with thermal ablation in the treatment of airway stenosis caused by lung cancer

作　　者：吴慈丽 张明华 WU Cili;ZHANG Minghua(Department of Medicine,Hubei University for Nationalities,Hubei Province,Enshi 445000,China;Department of Respiratory and Critical Diseases,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Hubei Province,Enshi 445000,China)

机构地区：[1]湖北民族大学医学部,湖北恩施445000 [2]湖北省恩施土家族苗族自治州中心医院呼吸与危重症学科,湖北恩施445000

出　　处：《中国当代医药》2022年第8期86-90,共5页China Modern Medicine

摘　　要：目的探讨经支气管镜下冷热联合消融治疗肺癌引发气道狭窄患者的临床效果。方法回顾性选取2020年1月至2021年6月恩施土家族苗族自治州中心医院收治的52例因肺癌引发气道狭窄患者作为研究对象,根据治疗方式不同分为观察组(26例)和对照组(26例),观察组采用冷热联合消融的方法,对照组采用单独行热消融的方法,比较两组临床疗效、治疗前后气促指数、卡氏体能状态评分(KPS),记录术中及术后并发症。结果治疗前两组气促指数和KPS评分比较,差异无统计学意义(P>0.05);治疗后两组气促指数低于治疗前,KPS评分高于治疗前,且观察组气促指数低于对照组,KPS评分高于对照组,差异有统计学意义(P<0.05)。观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组术中术后均未发生严重并发症。结论经支气管镜下冷热联合消融技术治疗肺癌引发气道狭窄患者的疗效好,且安全性高,对失去外科手术机会或拒接手术的患者提供了另一种治疗的方法。Objective To investigate the clinical effect of transbronchoscopic cryotherapy combined with thermal ablation in the treatment of airway stenosis caused by lung cancer.Methods Fifty-two patients with airway stenosis caused by lung cancer treated in Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from January 2020 to June 2021 were retrospectively selected as the research subjects.According to different treatment methods,they were divided into observation group(26 cases)and control group(26 cases).The observer used cryotherapy combined with thermal ablation,and the control group used thermal ablation.The clinical efficacy,shortness of breath index,Karnofsky performance score(KPS)were compared between the two groups after treatment,and surgical complications was recorded.Results Before treatment,there were no significant differences in breathlessness index and KPS score between the two groups(P>0.05).After treatment,the breathlessness indexes of the two groups were lower than those before treatment,and the KPS scores were higher than those before treatment,and the breathlessness index of the observation group was lower than that in the control group,and the KPS score was higher than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of observation group was higher than that in control group,the difference was statistically significant(P<0.05).No serious complications occurred in both groups.Conclusion transbronchoscopic cryotherapy combined with hot ablation in the treatment of airway stenosis caused by lung cancer can achieve satisfactory results,and it's safe.It provides another treatment for patients who lose the opportunity of surgery or refuse surgery.

关 键 词：支气管镜 冷消融 热消融 肺癌 气道狭窄 

分 类 号：R734.2[医药卫生—肿瘤]