生物制剂在口腔扁平苔藓治疗中的应用  

Role of biologics in the treatment of oral lichen planus

作　　者：孙雨桐 江潞[1] SUN Yutong;JIANG Lu(Department of Oral Medicine,West China Hospital of Stomatology,Sichuan University,State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院口腔黏膜病科,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川成都610041

出　　处：《口腔医学》2022年第3期261-265,共5页Stomatology

基　　金：国家自然科学基金面上项目(81872208);四川省科技创新基地(平台)和人才计划(20JCQN0242)。

摘　　要：口腔扁平苔藓(oral lichen planus, OLP)是一种病因不明、与自身免疫密切相关的慢性炎性疾病。皮质类固醇和免疫抑制剂是治疗OLP的常用药物,但部分OLP患者表现为不敏感或治疗抵抗。有研究提示生物制剂对治疗常规药物治疗不敏感或抵抗的OLP患者显示出优势。该文就治疗OLP生物制剂的种类、机制、疗效、预后及不良反应作一综述,为OLP的治疗提供参考。Oral lichen planus(OLP) is a chronic inflammatory disease of unknown etiology, and is closely related to autoimmunity. Corticosteroids and immunosuppressants are commonly used drugs for OLP treatment, but some OLP patients show insensitivity or treatment resistance. Research suggests that biologics have advantages for OLP patients that are not sensitive or are resistant to conventional drug treatment. This article reviews the types, mechanisms, efficacy, prognosis, and adverse reactions of biologics for OLP treatment and provides references for the treatment of OLP.

关 键 词：口腔扁平苔藓 生物制剂 治疗 

分 类 号：R781.5[医药卫生—口腔医学]