人β防御素2与口腔扁平苔藓相关性的研究进展  

Research advances in the relationship between human β defensin-2 and oral lichen planus

作　　者：黄辛兆 钟良军[1,2] HUANG Xinzhao;ZHONG Liangjun(School of Stomatology,Hangzhou Normal University,Hangzhou 311121,China)

机构地区：[1]杭州师范大学口腔医学院,浙江杭州311121 [2]杭州师范大学附属医院口腔医学中心牙周病诊疗中心,浙江杭州310015

出　　处：《口腔医学》2022年第3期276-279,共4页Stomatology

基　　金：2020年杭州市卫生科技计划重大项目(Z20200046)。

摘　　要：口腔扁平苔藓(oral lichen planus, OLP)是一种常见的口腔黏膜慢性免疫性炎症疾病,OLP的病因和发病机理目前尚未阐明,在临床诊疗过程中存在着诸多问题且OLP存在癌变风险,故OLP的发生发展及临床诊疗方面的研究历来受到重视。近年来的一些研究表明,OLP的发生与人β防御素2(humanβdefensin-2,hBD-2)有着密切关系。该文就OLP与hBD-2的相关研究进展进行总结及分析。Oral lichen planus(OLP) is a common chronic immune inflammatory disease that affects oral mucosa. However, the exact etiology of OLP has not yet been elucidated and valid diagnosis and treatment for OLP is inhibited by some factors with OLP itself a risk factor for malignant transformation. Therefore, research on the pathogenesis of OLP and treatment for OLP has been receiving much attention. In recent years, some studies have shown that OLP is closely related to human β defensin-2(hBD-2). This paper attempts to summarize and analyze recent research progress of OLP and hBD-2.

关 键 词：人Β防御素2 口腔扁平苔藓 抗菌肽 白念珠菌 

分 类 号：R781.5[医药卫生—口腔医学]