孤独症谱系障碍重复刻板行为与感觉门控相关性研究  

Correlation between repetitive and stereotyped behaviors and sensory gating in autism spectrum disorder

作　　者：郝汇睿 董献文 李恩耀[1] 樊亚蕾 成慧 江淼淼 赵鹏举[1] HAO Hui-rui;DONG Xian-wen;LI En-yao;FAN Ya-lei;CHENG hui;JIANG Miao-miao;ZHAO Peng-ju(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China)

机构地区：[1]郑州大学第五附属医院,河南郑州450052

出　　处：《中国儿童保健杂志》2022年第4期366-370,共5页Chinese Journal of Child Health Care

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190430);河南省医学科技攻关计划联合共建项目(2018020223);河南省卫健委省部共建重点项目(SBGJ202002123);河南省教育厅项目(21A320058)。

摘　　要：目的探究孤独症谱系障碍(ASD)儿童重复刻板行为的发育轨迹,明确其与大脑感觉门控之间的相关性,以期进一步为临床诊疗提供参考。方法选取2018年8月—2021年5月就诊于郑州大学第五附属医院儿童康复科门诊符合ASD诊断儿童89例,符合全面性发育迟缓(GDD)诊断儿童76例,采用重复行为量表-修订版(RBS-R)评价患儿重复刻板行为,采用感觉门控P50比值评价患儿大脑感觉门控,并分析二者的相关性。结果ASD及GDD儿童的重复刻板行为总分、低阶及高阶与感觉门控均无相关性(P>0.05)。ASD儿童重复刻板行为总分、低阶及高阶得分随年龄增长未见明显下降趋势(P>0.05),GDD儿童重复刻板行为与年龄呈明显负相关(r=-0.43~-0.23,P<0.05)。结论ASD儿童重复刻板行为发育轨迹并非简单的负性线性关系,其重复刻板行为与大脑感觉门控无明显相关性,P50可能不是一个有效预测重复刻板行为的指标。Objective To explore the developmental trajectory of restricted and repetitive behavior(RRB)in children with autism spectrum disorder(ASD),and to determine whether there is a correlation between RRB and sensory gating,so as to provide reference for clinical diagnosis and treatment.Methods From August 2018 to May 2021,89 children with ASD and 76 children with global developmental delay(GDD)in Children′s Rehabilitation Department of the Fifth Affiliated Hospital of Zhengzhou University were selected into this study.RRB was assessment by the Repetitive Behavior Scale-Revised(RBS-R),and cerebral sensory gating was evaluated by the sensory gating P50 ratio,and the correlation was analyzed.Results There was no significant correlation of the total scores,low-level and high-level of RRB with sensory gating in ASD children and GDD children(P>0.05).There was no significant decrease with age in the total scores,low-level and high-level of RRB in ASD children(P>0.05).However,RRB score was negatively related to the age of children with GDD(r=-0.43 to-0.23,P<0.01).Conclusions The developmental trajectory of RRB in ASD children is not a simple negative linear curve with age.There is no significant correlation between RRB and sensory gating.P50 may not be an effective index to predict repetitive and stereotyped behaviors.

关 键 词：孤独症谱系障碍 重复刻板行为 感觉门控 P50 

分 类 号：R749.94[医药卫生—神经病学与精神病学]