CTCs、ProGRP、NSE在小细胞肺癌诊断及预后评估中的临床价值  

Clinical value of CTCs,ProGRP and NSE in the diagnosis evaluation and prognosis of small cell lung cancer

作　　者：贾万理 杨阳[1] 晋婕 JIA Wanli;YANG Yang;JIN Jie(Department of Blood Transfusion,Xi′an Gaoxin Hospital,Xi′an,Shaanxi 710075,China;Xi′an Jinyu Medical Laboratory Co.LTD,Xi′an,Shaanxi 710075,China)

机构地区：[1]西安高新医院输血科,陕西西安710075 [2]西安金域医学检验所有限公司,陕西西安710075

出　　处：《检验医学与临床》2022年第8期1054-1056,1060,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨循环肿瘤细胞(CTCs)、胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)在小细胞肺癌诊断及预后评估中的临床价值。方法回顾性收集2017年1月到2018年6月西安高新医院收治的102例小细胞肺癌患者作为肺癌组,100例肺部良性肿瘤作为良性组,以及100例健康体检者作为对照组。比较3组CTCs、ProGRP、NSE水平,采用受试者工作特征(ROC)曲线分析CTCs、ProGRP、NSE单独和联合检测对小细胞肺癌的诊断效能,采用Cox回归模型分析小细胞肺癌预后的影响因素。结果肺癌组CTCs、ProGRP、NSE水平高于良性组及对照组(P<0.05)。CTCs、ProGRP、NSE联合检测诊断小细胞肺癌的曲线下面积为0.932,灵敏度为92.1%,特异度为90.0%,优于各项单独检测的诊断效能。Cox回归模型分析结果显示,临床分期为广泛期、有淋巴结转移及CTCs、ProGRP、NSE水平升高是小细胞肺癌预后不良的独立危险因素(P<0.05)。结论CTCs、ProGRP、NSE水平在小细胞肺癌患者中明显升高,且与患者预后密切相关,联合检测有助于患者早期诊断及预后评估,值得临床推广应用。Objective To investigate the clinical value of circulating tumor cells(CTCs),pro-gastrin-releasing peptide(ProGRP)and neuron-specific enolase(NSE)n the diagnosis and prognosis evaluation of small cell lung cancer.Methods From January 2017 to June 2018,102 patients with small cell lung cancer treated in Xi′an Gaoxin Hospital were retrospectively collected as the lung cancer group,100 patients with benign lung tumors as the benign group,and 100 healthy subjects as the control group.The levels of CTCs,ProGRP and NSE among the three groups were compared.The diagnostic efficacy of CTCs,ProGRP and NSE alone and in combination for small cell lung cancer was analyzed by the receiver operating characteristic(ROC)curve,and the influencing factors of prognosis for small cell lung cancer were analyzed by the Cox regression model.Results The levels of CTCs,ProGRP and NSE in the lung cancer group were higher than those in the benign group and the control group(P<0.05).The area under the curve of the combined detection of CTCs,ProGRP and NSE for the diagnosis of small cell lung cancer was 0.932,and the sensitivity was 92.1%,and the specificity was 90.0%,which was better than the diagnostic efficiency of single detection.The Cox regression model analysis showed that extensive clinical stage,lymph node metastasis and elevated levels of CTCs,ProGRP and NSE were independent risk factors for poor prognosis of small cell lung cancer(P<0.05).Conclusion CTCs,ProGRP and NSE levels significantly increase in patients with small cell lung cancer,and they are closely related to the prognosis of patients.Combined detection is helpful for early diagnosis and prognosis evaluation of patients,which is worthy of clinical application.

关 键 词：小细胞肺癌 循环肿瘤细胞 胃泌素释放肽前体 神经元特异性烯醇化酶 预后 

分 类 号：R734.2[医药卫生—肿瘤]