半夏白术天麻汤加减治疗风痰阻络型短暂性脑缺血发作伴颈动脉粥样硬化斑块患者的疗效及血液流变学分析  

Effect and hemorheological analysis of modified Banxia Baizhu Tianma Decoction in the treatment of patients with wind-phlegm-blocking collaterals type transient ischemic attack with carotid atherosclerotic plaque

作　　者：尚学振 SHANG Xuezhen(Department of Emergency,Xinxiang Hospital of Traditional Chinese Medicine,Xinxiang,Henan 453000,China)

机构地区：[1]河南省新乡市中医院急诊科,河南新乡453000

出　　处：《检验医学与临床》2022年第8期1092-1095,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨半夏白术天麻汤加减治疗风痰阻络型短暂性脑缺血发作伴颈动脉粥样硬化斑块患者的临床效果。方法选取2019年1月至2021年1月50例风痰阻络型短暂性脑缺血发作伴颈动脉粥样硬化斑块患者作为研究对象,依照治疗方案不同分为观察组、对照组,每组25例。对照组给予常规西医治疗,观察组在对照组基础上给予半夏白术天麻汤加减治疗。比较2组治疗效果及治疗前后中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分、改良日常生活能力评估量表(mBI)评分、颈动脉粥样硬化斑块指数、血液流变学指标[全血黏度、纤维蛋白原(Fib)、血细胞比容]、血清生化指标水平[同型半胱氨酸(Hcy)、总胆固醇(TC)、高密度脂蛋白(HDL)]。结果观察组总有效率为96.00%,明显高于对照组的68.00%(P<0.05)。治疗后,观察组中医证候积分、NIHSS评分、颈动脉粥样硬化斑块指数、全血黏度及Fib、Hcy、TC水平均低于对照组(P<0.05),mBI评分、HDL水平均高于对照组(P<0.05)。结论半夏白术天麻汤加减治疗风痰阻络型短暂性脑缺血发作伴颈动脉粥样硬化斑块患者效果显著,可明显缓解其临床症状,提高患者生活质量。Objective To investigate the clinical effect of Banxia Baizhu Tianma Decoction in the treatment of patients with wind-phlegm-blocking collaterals type transient ischemic attack with carotid atherosclerotic plaque.Methods From January 2019 to January 2021,50 patients with wind-phlegm-blocking collaterals type transient ischemic attack with carotid atherosclerotic plaque were selected as the research object,and they were divided into observation group and control group according to different treatment schemes,with 25 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Banxia Baizhu Tianma Decoction on the basis of the control group.The treatment effects and scores of Traditional Chinese Medicine syndromes,the United States national institutes of health stroke scale(NIHSS)score,the modified ability of daily living(mBI)score,carotid atherosclerotic plaque index,hemorheological indicators[whole blood viscosity,fibrinogen(Fib),hematocrit],serum biochemical indicator levels[homocysteine(Hcy),total cholesterol(TC),high-density lipoprotein(HDL)]before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 96.00%,which was higher than the 68.00%of the control group(P<0.05).After treatment,the scores of Traditional Chinese Medicine syndromes,NIHSS score,carotid atherosclerotic plaque index,whole blood viscosity and the serum levels of Fib,Hcy and TC in the observation group were lower than those in the control group(P<0.05),and the mBI score and HDL levels were higher than those in the control group(P<0.05).Conclusion Banxia Baizhu Tianma Decoction has a significant effect on the treatment of wind-phlegm-blocking collaterals type transient ischemic attack with carotid atherosclerotic plaque,which can significantly relieve the clinical symptoms and improve the quality of patient′s life.

关 键 词：半夏白术天麻汤 风痰阻络型 短暂性脑缺血发作 颈动脉粥样硬化斑块 血液流变学 

分 类 号：R743.31[医药卫生—神经病学与精神病学]