Ocular development in children with unilateral congenital cataract and persistent fetal vasculature  

作　　者：Shu-Yi Zhang Hui Chen Jing-Hui Wang Wan Chen Qi-Wei Wang Jing-Jing Chen Xiao-Shan Lin Zhuo-Ling Lin Duo-Ru Lin Hao-Tian Lin Wei-Rong Chen 

机构地区：[1]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,Guangdong Province,China [2]Center for Precision Medicine,Sun Yat-sen University,Guangzhou 510060,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第3期426-431,共6页国际眼科杂志（英文版）

基　　金：Supported by the National Key R&D Program of China (No.2020YFC2008200);the National Natural Science Foundation of China (No.81970813;No.81970778;No.82000946);the Natural Science Foundation of Guangdong Province (No.2020A1515010987;No.2021A1515012238);Guangzhou Municipal Science and Technology Project (No.201904010062)。

摘　　要：AIM: To investigate the ocular development of patients who had unilateral congenital cataract(CC) combined with persistent fetal vasculature(PFV).METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral CC.Axial length(AL), keratometry, anterior chamber depth(ACD), lens thickness, and vitreous length were obtained.The ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated CC.RESULTS: A total of 110 patients were included and divided into 4 groups: group 1(18 patients with CC and PFV, <24 mo), group 2(22 patients with CC and PFV, ≥24 mo), group 3(35 patients with CC, <24 mo), and group 4(35 patients with CC, ≥24 mo).The ALs of the affected eyes were shorter than those of the fellow eyes in group 1(20.02±1.06 vs 20.66±0.63 mm, P=0.025).While the ALs of the affected eyes were longer than those of the fellow eyes in group 2(23.18±2.00 vs 22.31±1.06 mm, P=0.044) and group 4(22.64±1.80 vs 22.02±1.01 mm, P=0.033).The keratometries of the affected eyes were steeper than those of the fellow eyes in group 2(44.78±1.66 vs 43.83±1.38 D,P=0.041) and group 4(43.76±1.91 vs 43.34±1.46 D, P=0.043).No difference of ACDs between two eyes was found in all groups(all P>0.05).CONCLUSION: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24 mo and longer in those older than 24 mo;the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24 mo and similar with those younger than 24 mo.These findings provide further understanding of ocular development in patients with both CC and PFV.

关 键 词：ocular development congenital cataract persistent fetal vasculature axial length KERATOMETRY 

分 类 号：R776.1[医药卫生—眼科]