Scleral remodeling in myopia development  

作　　者：Qi Yu Ji-Bo Zhou 

机构地区：[1]Department of Ophthalmology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China [2]Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology,Shanghai 200011,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第3期510-514,共5页国际眼科杂志（英文版）

摘　　要：With the increasing prevalence in recent years, myopia has become an essential global health concern.In most instances, an increased axial length of the eye is the structural cause of nearsightedness.The scleral remodeling, primarily dependent on the scleral extracellular matrix(ECM) changes, is significantly linked to eye lengthening.Scleral remodeling plays a critical function in the incidence and progression of myopia.This mini-review will focus on recent research progress of scleral remodeling in the hope of providing new ideas for the prophylaxis and treatment of myopia.

关 键 词：scleral remodeling MYOPIA extracellular matrix hypoxia-inducible factor-1α MMPS/TIMPS 

分 类 号：R778.11[医药卫生—眼科]