Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing  

作　　者：Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo 

机构地区：[1]Second Department of General Surgery,Shaanxi Provincial People’s Hospital,Xi’an,710068,China [2]Frontier Institute of Science and Technology,and State Key Laboratory for Mechanical Behavior of Materials,and Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University,Xi’an,710049,China [3]Second Department of General Surgery,Third Affiliated Hospital of Xi’an Jiaotong University,Xi’an,710068,China

出　　处：《Bioactive Materials》2022年第2期341-354,共14页生物活性材料（英文）

基　　金：jointly supported by the National Natural Science Foundation of China(grant numbers:51973172,and 51673155);the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020);State Key Laboratory for Mechanical Behavior of Materials,and the Fundamental Research Funds for the Central Universities;the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities;Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008);the Key R&D Program of Shaanxi Province(No.2019ZDLSF02-09-01,2020GXLH-Y-019);Innovation Capability Support Program of Shaanxi Province(Program No.2019GHJD-14,2021TD-40);Scientific Research Program Funded by Shaanxi Provincial Education Department(Program No.18JC027).

摘　　要：With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious challenge.In order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing.The mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests.These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model.In addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were measured.The inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were studied.All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.

关 键 词：Chitosan Wound dressing ANTIBACTERIAL Wound healing HEMOSTAT Infected skin wound 

分 类 号：O63[理学—高分子化学]