Niobium carbide(MXene)reduces UHMWPE particle-induced osteolysis  

作　　者：Kuo-Yang Sun Yizhang Wu Jia Xu Wenfang Xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv XSWu Qing Jiang Hong-Ling Cai Dongquan Shi 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,Department of Sports Medicine and Adult Reconstructive Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,321 Zhongshan Road,Nanjing,210008,Jiangsu,PR China [2]Collaborative Innovation Center of Advanced Microstructures,Laboratory of Solid State Microstructures and School of Physics,Nanjing University,Nanjing,210093,China [3]Drum Tower of Clinical Medicine,Nanjing Medical University,Nanjing,210008,Jiangsu,PR China [4]Department of Gastroenterology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,321 Zhongshan Road,Nanjing,210008,Jiangsu,PR China

出　　处：《Bioactive Materials》2022年第2期435-448,共14页生物活性材料（英文）

基　　金：supported by National Key R&D Program of China(2018YFC1105904,2016YFA0201104);National Science Foundation of China(81772335,81941009,81802196,11874200);Natural Science Foundation of Jiangsu Province,China(BK20180127);Jiangsu Provincial Key Medical Talent Foundation;Six Talent Peaks Project of Jiangsu Province(WSW-079).

摘　　要：Joint replacement surgery is one of the orthopedic surgeries with high successful rates;however,wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant.The implant-derived particulate debris such as ultrahigh molecular weight polyethylene(UHMWPE)can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species(ROS).ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of osteolysis.In this work,we develop the few-layered Nb_(2)C(FNC)as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS adsorption.Moreover,local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial model.In sum,our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.

关 键 词：Periprosthetic osteolysis MXene Niobium carbide OSTEOCLASTOGENESIS Reactive oxygen species(ROS) 

分 类 号：R318[医药卫生—生物医学工程]