内皮抑素、凝血酶敏感蛋白-1表达与慢性荨麻疹患者并发血管性水肿相关性及临床意义  

Correlations between Expressions of Endostatin and Thrombin Sensitive Protein-1 with Angioedema in Patients with Chronic Urticaria and Their Clinical Significances

作　　者：周美联 卢彬 ZHOU Mei-lian;LU Bin(Department of Dermatology and Venereology,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China)

机构地区：[1]定州市人民医院皮肤性病科,河北定州073000

出　　处：《解放军医药杂志》2022年第4期77-80,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨内皮抑素(ES)、凝血酶敏感蛋白-1(TSP-1)表达与慢性荨麻疹患者并发血管性水肿相关性及临床意义。方法选取2020年8月—2021年8月收治的慢性荨麻疹118例,根据是否并发血管性水肿分为发生组54例和未发生组64例。比较2组ES、TSP-1及7日荨麻疹活动度评分(UAS7)、血管性水肿活动度评分(AAS),应用Pearson相关分析ES、TSP-1间及与UAS7评分、AAS评分的相关性,采用多因素Logistic回归分析并发血管性水肿的影响因素,采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析ES、TSP-1及联合预测慢性荨麻疹并发血管性水肿的价值。结果发生组ES、TSP-1水平低于未发生组,UAS7、AAS评分高于未发生组(P<0.01)。ES与TSP-1呈正相关(r=0.560,P<0.001);ES与UAS7评分、AAS评分呈负相关(r=-0.643、-0.560,P<0.001),TSP-1与UAS7评分、AAS评分呈负相关(r=-0.577、-0.500,P<0.001)。ES、TSP-1均与血管性水肿的发生显著相关(P<0.01)。ES联合TSP-1预测并发血管性水肿的AUC大于单一ES、TSP-1检测(P<0.01)。结论ES、TSP-1表达与慢性荨麻疹患者并发血管性水肿有关,并与患者病情活动度有关,联合检测可作为预测并发血管性水肿的有效方案。Objective To investigate correlations between expressions of endostatin(ES)and thrombin sensitive protein-1(TSP-1)with angioedema in patients with chronic urticaria and their clinical significances.Methods A total of 118 patients with chronic urticaria admitted between August 2020 and August 2021 were selected and divided into occurrence group(n=54)and non-occurrence group(n=64)according to whether or not complication of angioedema.Expressions of ES and TSP-1,7-day urticaria activity score(UAS7)and angioedema activity score(AAS)were compared between two groups.Pearson correlation analysis was used to analyze the correlation between ES and TSP-1 and their correlations with scores of UAS7 and AAS.Multivariate Logistic regression analysis was used to analyze the influencing factors of complicated angioedema.Receiver operating characteristics(ROC)curve and area under the ROC curve(AUC)were used to analyze values of ES and TSP-1 alone and their combination in prediction of patients with chronic urticaria complicated by angioedema.Results In occurrence group,expressions of ES and TSP-1 were significantly lower,while scores of UAS7 and AAS were significantly higher than those in non-occurrence group(P<0.01).ES was positively correlated with TSP-1(r=0.560,P<0.001),and it negatively correlated with scores of UAS7 and AAS(r=-0.643,-0.560,P<0.001).TSP-1 was negatively correlated with scores of UAS7 and AAS(r=-0.577,-0.500,P<0.001).ES and TSP-1 were significantly correlated with the occurrence of angioedema(P<0.01).The AUC of ES combined with TSP-1 in prediction of angioedema in patients with chronic urticaria was significantly greater than those by ES or TSP-1 alone(P<0.01).Conclusion Expressions of ES and TSP-1 are related to angioedema in patients with chronic urticaria,and they are related to the activity of patients'conditions.Combined detection of the two indexes may be used as an effective scheme to predict angioedema.

关 键 词：荨麻疹 内皮抑素类 凝血酶敏感蛋白1 血管性水肿 预测 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]