局限期小细胞肺癌预防性脑照射后脑转移相关危险因素分析  

Analysis of risk factors associated with brain metastasis of limited small cell lung cancer after prophylactic cranial irradiation

作　　者：李明旭 胡松柳[1] Li Mingxu;Hu Songliu(Department of Radiation Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院放疗科,哈尔滨150081

出　　处：《中华放射肿瘤学杂志》2022年第4期395-399,共5页Chinese Journal of Radiation Oncology

基　　金：国家癌症中心攀登基金(NCC201808B015);中国医疗手牵手工程委员会-北京医学奖励基金会基金(YXJL-2020-0961-0159)。

摘　　要：小细胞肺癌具有易复发和转移的生物学特点,脑是小细胞肺癌肺外转移的好发部位。局限期小细胞肺癌患者行预防性脑照射(PCI)能够有效降低脑转移的发生率,延长总生存期。但是在PCI后仍有近1/3的患者发生脑转移。本文对PCI后脑转移的危险因素进行综述,目的在于判断何种局限期小细胞肺癌亚组患者能够从PCI中获益,从而为PCI的临床应用提供参考。Small cell lung cancer(SCLC)has the biological characteristics of high recurrence and metastasis.The brain is the common site of SCLC extrapulmonary metastasis.Prophylactic cranial irradiation(PCI)can effectively reduce the incidence of brain metastasis and prolong the overall survival of patients with limited SCLC.Nevertheless,nearly one third of patients develop brain metastases after PCI.This article reviews the risk factors of brain metastasis after PCI,aiming to determine which subgroup of patients with limited SCLC can benefit from PCI and provide reference for the clinical application of PCI.

关 键 词：癌 小细胞肺 预防性脑照射 脑转移 危险因素 

分 类 号：R734.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]