乳源外泌体研究进展  

Research Progress of Milk-derived Exosomes

作　　者：丁军 付子琳 和俊豪 段晓微 马露[1] 卜登攀[1,2] DING Jun;FU Zilin;HE Junhao;DUAN Xiaowei;MA Lu;BU Dengpan(State Key Laboratory of Animal Nutrition,Institute of Animal Science,Chinese Academy of Agricultural Sciences, Beijing 100193,China;Chinese Academy of Agricultural Sciences and World Agroforestry Center Joint Lab on Agroforestry and Sustainable Animal Husbandry, Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所动物营养学国家重点实验室,北京100193 [2]中国农业科学院与世界农用林业中心农用林业与可持续畜牧业联合实验室,北京100193

出　　处：《畜牧兽医学报》2022年第4期1019-1029,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：宁夏回族自治区重点研发计划项目(2021BEF02018);中国农业科学院科技创新工程(ASTIP-IAS07-1);奶牛产业技术体系北京市创新团队(BAIC06-2021)。

摘　　要：外泌体(exosomes)是一种纳米级别的细胞外囊泡,广泛存在于多种动物的组织和体液中,在各种类型的细胞外囊泡中,外泌体作为一个载体可以携带多种具有生物活性的内含物,而这些内含物的分拣是一个受调控的、非随机的过程。近年来,有研究发现,哺乳动物的乳源外泌体通过消化道被吸收后,可以促进幼畜肠道和免疫系统的发育,同时还参与一些疾病的发生发展过程。本文将对外泌体的产生及功能、乳源外泌体的结构、乳源外泌体的提取鉴定以及乳源外泌体的应用加以综述,为进一步研究乳源外泌体奠定基础。Exosomes are nano-level extracellular vesicles,which are widely present in the tissues and body fluids of a variety of animals.In various types of extracellular vesicles,exosomes can carry multiple compounds with biological activity.At the same time,the sorting of compounds in exosomes is a regulated and non-random process.In recent years,studies have shown that milk-derived exosomes can promote development of the intestinal and immune system of young animals after being absorbed in digestive tract,and they are also involved in some disease processes.This article reviews the production and function of exosomes,the extraction and identification of milk-derived exosomes,as well as their application of milk exosomes,in order to provide the theoretical foundation for further research on milk-derived exosomes.

关 键 词：乳源外泌体 功能特性 应用 

分 类 号：S852.2[农业科学—基础兽医学]