Porous tantalum structure integrated on Ti6Al4V base by Laser Powder Bed Fusion for enhanced bony-ingrowth implants:In vitro and in vivo validation  

作　　者：Pengfei Lei Hu Qian Taomei Zhang Ting Lei Yihe Hu Chao Chen Kechao Zhou 

机构地区：[1]Department of Orthopedic Surgery,Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants,Xiangya Hospital,Central South University,Changsha 410008,China [2]Department of Orthopedic Surgery,The First Affiliated Hospital,College of Medicine,Zhejiang University,China [3]State Key Laboratory of Powder Metallurgy,Central South University,Changsha,410083,China

出　　处：《Bioactive Materials》2022年第1期3-13,共11页生物活性材料（英文）

基　　金：This study was supported by the Natural Science Foundation of Hunan Province,China(Grant No.2019JJ40499);the Scientific Research Project of Health and Family Planning Commission of Hunan Province,China(Grant No.B2019188);the Science and technology Innovation Leading Project for High-tech Industry of Hunan Province(Grant No.2020SK2008);the Major science and technology projects of Changsha City(Grant No.42193);National key research and development project(2018YFB1105504);Natural Science Foundation of China(Grant No.82002277 and 81672656).

摘　　要：Despite the widespread application of Ti6Al4V and tantalum(Ta)in orthopedics,bioinertia and high cost limit their further applicability,respectively,and tremendous efforts have been made on the Ti6Al4V-Ta alloy and Ta coating to address these drawbacks.However,the scaffolds obtained are unsatisfactory.In this study,novel high-interface-strength Ti6Al4V-based porous Ta scaffolds were successfully manufactured using Laser Powder Bed Fusion for the first time,in which porous Ta was directly manufactured on a solid Ti6Al4V substrate.Mechanical testing revealed that the novel scaffolds were biomechanically compatible,and the interfacial bonding strength was as high as 447.5 MPa.In vitro biocompatibility assay,using rat bone marrow mesenchymal stem cells(r-BMSCs),indicated that the novel scaffolds were biocompatible.Alkaline phosphatase and mineralized nodule determination demonstrated that the scaffolds favored the osteogenic differentiation of r-BMSCs.Moreover,scaffolds were implanted into rabbits with femur bone defects,and imaging and histological evaluation identified considerable new bone formation and bone ingrowth,suggesting that the scaffolds were well integrated with the host bone.Overall,these results demonstrated good mechanical compatibility,biocompatibility,and osteointegration performance of the novel Ti6Al4V-based porous Ta scaffold,which possesses great potential for orthopedic clinical applications.

关 键 词：Tantalum TI6AL4V Laser powder bed fusion Orthopedic scaffolds OSTEOINTEGRATION 

分 类 号：R318[医药卫生—生物医学工程] TB3[医药卫生—基础医学]