姜黄素介导光动力治疗口腔感染性疾病的研究进展  

Research progress on curcumin⁃mediated photodynamic therapy for oral infectious diseases

作　　者：周子伊 任彪[2] 周学东[1] ZHOU Ziyi;REN Biao;ZHOU Xuedong(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan Universi-ty,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科,四川成都610041 [2]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,四川成都610041

出　　处：《口腔疾病防治》2022年第8期588-593,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(81870778);四川省科技计划资助项目(2020YJ0227)。

摘　　要：姜黄素是一种天然药物,来源广泛、毒性低,具有抗细菌、抗真菌、抗炎等多种药理作用。近年来,姜黄素在口腔感染性疾病防治领域备受关注。单一姜黄素在应用中易降解、水溶性差、生物利用率较低,但它可作为一种天然光敏剂,可介导光动力治疗口腔感染性疾病。光动力治疗抗菌效率高,可较好地保护患处的美观和功能。本文就姜黄素介导光动力治疗口腔感染性疾病的研究进行综述。研究结果表明,姜黄素作为天然光敏剂介导光动力治疗,通过增强抗菌能力、提升活性氧物种产量、抑制生物膜形成等方式,对龋病、牙髓根尖周疾病、牙周炎、口腔念珠菌病等口腔感染性疾病展现出良好的治疗作用。深入探究姜黄素介导光动力治疗在不同口腔感染性疾病中的作用机制,为口腔感染性疾病的防治提供新的策略。Curcumin is a natural medicine with a wide range of sources and low toxicity.It has antibacterial,antifun⁃gal,anti⁃inflammatory and other pharmacological effects.In recent years,curcumin has attracted much attention in the field of prevention and treatment of oral infectious diseases.Single curcumin is easily degraded during application and has poor water solubility and low bioavailability,but it can be used as a natural photosensitizer to mediate photodynam⁃ic treatment of oral infections.Photodynamic therapy has high antibacterial efficiency and can better protect the appear⁃ance and function of the affected area.This article reviews the research on curcumin⁃mediated photodynamic therapy for oral infectious diseases.As a natural photosensitizer,curcumin mediates photodynamic therapy and has shown good therapeutic effects against dental caries,endodontics,periodontitis,oral candidiasis and other oral infectious diseases by enhancing antibacterial ability,increasing the production of reactive oxygen species,and inhibiting the formation of biofilms.In⁃depth exploration of the mechanism of action of curcumin⁃mediated photodynamic therapy in different oral infectious diseases can provide new strategies for the prevention and treatment of oral infectious diseases.

关 键 词：姜黄素 光动力治疗 光敏剂 龋病 牙髓根尖周疾病 牙周炎 口腔念珠菌病 口腔感染性疾病 

分 类 号：R78[医药卫生—口腔医学]