非典型抗精神病药物治疗不同性别青少年精神分裂症患者疗效及对代谢的影响研究  

Study on the Efficacy and Metabolism of Atypical Antipsychotics in the Treatment of Adolescents with Schizophrenia

作　　者：朱利红 何艳平 ZHU Li-hong;HE Yan-ping(Department of Children and Adolescents,Luoyang Fifth People's Hospital,Luoyang 471000,Henan Province,China)

机构地区：[1]洛阳市第五人民医院儿童青少年科,河南洛阳471000

出　　处：《罕少疾病杂志》2022年第5期27-28,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的研究非典型抗精神病药物治疗不同性别青少年精神分裂症患者的临床疗效及对代谢功能的影响。方法选取洛阳市第五人民医院收治的190例精神分裂症青少年患者为研究对象,根据性别不同分为男性组(n=95)和女性组(n=95),两组均给予非典型的抗精神病药物治疗。比较两组临床疗效、体质量及血清指标。结果与治疗前比较,治疗后两组体质量、TG、LDL、UA均有增高(P<0.05);与女性组比较,治疗后男性组UA增高更显著(P<0.05)。两组治疗总有效率比较(86.32%VS83.16%),差异没有统计学意义(P<0.05)。结论使用抗精神病药物治疗青少年精神分裂症时,对不同性别患者具有相似疗效,但对男性患者的代谢影响更大。Objective To study the efficacy of atypical antipsychotics in the treatment of adolescent schizophrenia of different genders and its effect on metabolic function.Methods 190 adolescent patients with schizophrenia treated in Luoyang Fifth People’s hospital were selected as the research object.They were divided into male group(n=95)and female group(n=95)according to gender.Both groups were treated with atypical antipsychotics.The clinical efficacy,body mass and serum indexes of the two groups were compared.Results Compared with before treatment,the body mass,TG,LDL and UA of the two groups increased after treatment(P<0.05);Compared with female group,UA in male group increased more significantly after treatment(P<0.05).There was no significant difference between the two groups(86.32%vs 83.16%)(P<0.05).Conclusion The use of antipsychotics in the treatment of adolescent schizophrenia has similar curative effects on patients of different genders,but has a greater impact on the metabolism of male patients.

关 键 词：贝前列素钠 脑小血管病 认知功能 血浆水平 

分 类 号：R749.3[医药卫生—神经病学与精神病学]