乳腺X线密度对乳腺癌新辅助化疗治疗效应预测价值分析  

Predictive Value of Mammographic Density on the Effect of Neoadjuvant Chemotherapy Treatment for Breast Cancer

作　　者：魏锦洪 崔世恩[1] 凌飞海[1] 郭子柏 孙桃梅 WEI Jin-hong;CUI Shi-en;LING Fei-hai;GUO Zi-bai;SUN Tao-mei(Breast Disease Diagnosis and Treatment Center,Zhongshan People's Hospital,Zhongshan 528400,Guangdong Province,China;Department of Gynecology,Zhongshan People's Hospital,Zhongshan 528400,Guangdong Province,China)

机构地区：[1]中山市人民医院乳腺疾病诊治中心,广东中山528400 [2]中山市人民医院妇科一区,广东中山528400

出　　处：《罕少疾病杂志》2022年第5期59-61,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的本研究调查了新辅助化疗前评估的乳腺X线密度是否能预测病理完全反应(pCR)。方法本研究回顾性分析了2015年6月至2019年12月在我院进行乳腺癌新辅助化疗的197名患者。全部患者在接受新辅助化疗前接受乳腺钼靶X线摄影检查,根据第5版BI-RADS对患者乳腺钼靶X线摄影结果进行分类。使用多元逻辑回归分析探讨乳腺X线密度与pCR的相关性,并按照患者绝经状态进行分层分析。结果与乳腺X线密度较低患者(BI-RADS a)患者相比,乳腺X线密度较高患者完成pCR的OR呈下降趋势。与BI-RADS a的患者相比,多变量调整模型中完成pCR的OR为BI-RADS b 0.67[95%置信区间(CI)0.21~1.31],BIRADS c 0.40(95%CI 0.27~1.09),以及BI-RADS d 0.29(95%CI 0.013~1.068)。结论与乳房X线密度较低的患者相比,乳房X线密度较高的患者在新辅助化疗后达到pCR的可能性较小。Objective This study investigated whether mammographic density assessed before neoadjuvant chemotherapy predicted pathologic complete response(pCR).Methods This study retrospectively analyzed 197 patients who underwent neoadjuvant chemotherapy for breast cancer at our institution from June 2015 to December 2019.All patients underwent mammography before receiving neoadjuvant chemotherapy,and patients were classified according to the 5th edition of BI-RADS for mammography findings.The correlation between mammographic density and pCR was investigated using multiple logistic regression analysis and stratified according to the patients’menopausal status.Results Patients with higher mammographic density had a decreasing trend in OR to complete pCR compared to patients with lower mammographic density(BI-RADS a).Compared to patients with BI-RADS a,the ORs for completing pCR in the multivariate adjusted model were BI-RADS b 0.67[95%confidence interval(CI)0.21-1.31],BI-RADS c 0.40(95%CI 0.27-1.09),and BI-RADS d 0.29(95%CI 0.013-1.068).Conclusion Patients with higher mammographic density were less likely to achieve pCR after neoadjuvant chemotherapy compared with those with lower mammographic density.

关 键 词：乳腺X线密度 乳腺癌 新辅助化疗 治疗效应预测 

分 类 号：R737.9[医药卫生—肿瘤]