基质金属蛋白酶11、巨噬细胞抑制细胞因子-1联合检测对结直肠癌诊断及预后评估的价值  

Value of combined matrix metalloproteinase 11 and macrophage inhibitory cytokine-1 detection in diagnosis and prognosis evaluation of colorectal cancer

作　　者：易默[1] 吕飒美[1] 都庆国[2] 张健[1] 吴友伟[1] YI Mo;LYU Samei;DU Qingguo;ZHANG Jian;WU Youwei(Department of Gastroenterology II,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China;Department of General Surgery II,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China)

机构地区：[1]陕西省人民医院消化内二科,西安710068 [2]陕西省人民医院普外二科,西安710068

出　　处：《癌症进展》2022年第5期505-507,512,共4页Oncology Progress

摘　　要：目的 分析基质金属蛋白酶11(MMP11)、巨噬细胞抑制细胞因子-1(MIC-1)联合检测在结直肠癌诊断及预后评估中的应用价值。方法 收集92例疑似结直肠癌患者的临床资料,以病理结果作为金标准,分析MMP11、MIC-1检测对结直肠癌的诊断价值,比较良恶性疾病患者MMP11、MIC-1的表达,并采用多元Logistic回归分析对影响结直肠癌患者预后的危险因素进行分析。结果 经病理活检,92例疑似结直肠癌患者最终确诊为结直肠癌75例。MMP11联合MIC-1检测诊断结直肠癌的灵敏度(85.33%)、特异度(82.35%)及准确度(84.78%)分别高于MMP11(68.00%、58.82%、66.30%)及MIC-1(70.67%、64.71%、69.57%)单独检测。结直肠癌患者MMP11、MIC-1高表达率均高于结直肠息肉及良性大肠炎患者,差异均有统计学意义(P﹤0.05)。生存与死亡结直肠癌患者分化程度、Enneking外科分期、淋巴结转移情况、MMP11表达情况、MIC-1表达情况比较,差异均有统计学意义(P﹤0.05)。多因素分析结果显示,分化程度为低分化、Enneking外科分期为Ⅲ~Ⅳ期、淋巴结转移、MMP11高表达和MIC-1高表达均为结直肠癌患者术后死亡的独立危险因素(P﹤0.01)。结论 MMP11、MIC-1是影响结直肠癌手术患者预后的危险因素,通过联合检测MMP11、MIC-1水平可有效对结直肠癌进行术前诊断、预后评估。Objective To analyze the application value of combined detection of matrix metalloproteinase 11(MMP11) and macrophage inhibitory cytokine-1(MIC-1) in the diagnosis and prognosis evaluation of colorectal cancer.Method The clinical data of 92 patients with suspected colorectal cancer were collected, and the pathological results were used as the gold standard to analyze the diagnostic value of MMP11 and MIC-1 detection in colorectal cancer, and the expressions of MMP11 and MIC-1 in patients with benign and malignant diseases were also compared. Logistic regression analysis was performed to analyze the risk factors for the prognosis of patients with colorectal cancer. Result Through the pathological biopsy, 75 cases were finally diagnosed with colorectal cancer among 92 patients with suspected colorectal cancer. The sensitivity(85.33%), specificity(82.35%), and accuracy(84.78%) of MMP11 combined with MIC-1 in the diagnosis of colorectal cancer were higher than those with single MMP11(68.00%, 58.82%, 66.30%) and MIC-1(70.67%, 64.71%, 69.57%), respectively. The high expression rates of MMP11 and MIC-1 in patients with colorectal cancer were higher than those in patients with colorectal polyps and benign colitis, and the differences were statistically significant(P<0.05). There were significant differences in the differentiation grade, Enneking surgical stage, lymph node metastasis, MMP11 expression, and MIC-1 expression between living and dead colorectal cancer patients(P<0.05).The results of the multivariate analysis indicated that the poorly differentiated, Enneking surgical Ⅲ-Ⅳ stage, lymph node metastasis, high expression of MMP11, and high expression of MIC-1 were independent risk factors for postoperative death in patients with colorectal cancer(P<0.01). Conclusion MMP11 and MIC-1 are risk factors for the prognosis of patients with colorectal cancer surgery. The combined detection of MMP11 and MIC-1 levels could effectively help preoperative diagnosis and prognosis evaluation for colorectal cancer.

关 键 词：结直肠癌 基质金属蛋白酶11 巨噬细胞抑制细胞因子-1 预后 

分 类 号：R735.7[医药卫生—肿瘤]