激素对圆锥角膜的影响及其作用机制  

Effect of hormones on keratoconus and its mechanism

作　　者：赵晓瑞 袁翌斐 张钰[1] 陈跃国[1] Zhao Xiaorui;Yuan Yifei;Zhang Yu;Chen Yueguo(Department of Ophthalmology,Peking University Third Hospital,Beijing Key Laboratory of Restoration of Damaged Ocular Nerve,Peking University Third hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院眼科眼部神经损伤的重建保护与康复北京市重点实验室,北京100191

出　　处：《中华眼科杂志》2022年第4期309-314,共6页Chinese Journal of Ophthalmology

摘　　要：圆锥角膜是一种扩张性角膜疾病,表现为中央或颞下侧角膜局部变薄扩张呈圆锥状隆起。研究显示其发病与体内组织蛋白、酶、免疫功能、遗传基因等的改变相关,但确切的发病机制目前尚无定论。以性激素为代表的多种激素已被发现对于圆锥角膜的发生和发展产生一定的影响。本综述旨在总结分析激素对圆锥角膜影响及其作用机制的研究进展,探求激素在圆锥角膜早期诊断中的可能作用,以期发现圆锥角膜治疗中的新靶点,为临床及今后的研究工作提供参考。Keratoconus is an ectatic corneal disorder and characterized by central and/or inferior temporal corneal thinning in a cone shape.Studies have shown that its pathogenesis is related to changes in tissue proteins,enzymes,immune functions and specific genes,but the exact pathogenesis has not been clearly clarified yet.Hormones such as sex hormones have been found to be associated with keratoconus.This review aims to summarize and analyze the research progress of the effect of hormones on keratoconus and its mechanism,so as to explore the role of hormones in the early diagnosis of keratoconus and find new targets in the treatment of keratoconus,providing reference for clinical work.

关 键 词：圆锥角膜 激素类 胶原 

分 类 号：R772.2[医药卫生—眼科]