星形胶质细胞大麻素信号和行为  

Astroglial cannabinoid signaling and behavior

作　　者：Carla Ramon-Duaso Ana Rocio Conde-Moro Arnau Busquets-Garcia 杜一星(编译) 

机构地区：[1]Cell-Type Mechanisms in Normal and Pathological Behavior Research Group,Neuroscience Programme,IMIM Hospital del Mar Medical Research Institute,Barcelona,Spain [2]不详

出　　处：《神经损伤与功能重建》2022年第4期248-248,共1页Neural Injury and Functional Reconstruction

摘　　要：在神经科学中,创新和先进技术成就的爆炸式增长是理解大脑功能的基础。例如,在突触水平上区分神经胶质和神经元活动的可能性,以及特异性监测和调控星形胶质细胞功能的新遗传工具的出现,揭示了星形胶质细胞多方面参与行为的控制机制。从这个意义上说,星形胶质细胞中存在功能性1型大麻素受体的发现导致确定了由这种特定的大麻素受体库介导的重要行为反应。因此,星形胶质细胞1型大麻素受体非常适合在下列复杂场景中发挥作用:星形胶质细胞感知神经元活动,释放胶质递质和调节其他神经元活动,最终控制行为反应。在本综述中,我们将对已知的星形胶质细胞大麻素信号系统对行为的影响机制进行综述,并重点探讨关于星形胶质细胞大麻素信号传导如何影响行为的有待进一步探索的研究途径。In neuroscience,the explosion of innovative and advanced technical accomplishments is fundamental to understanding brain functioning.For example,the possibility to distinguish glial and neuronal activities at the synaptic level and/or the appearance of new genetic tools to specifically monitor and manipulate astroglial functions revealed that astrocytes are involved in several facets of behavioral control.In this sense,the discovery of functional presence of type-1 cannabinoid receptors in astrocytes has led to identify important behavioral responses mediated by this specific pool of cannabinoid receptors.Thus,astroglial type-1 cannabinoid receptors are in the perfect place to play a role in a complex scenario in which astrocytes sense neuronal activity,release gliotransmitters and modulate the activity of other neurons,ultimately controlling behavioral responses.In this review,we will describe the known behavioral implications of astroglial cannabinoid signaling and highlight exciting unexplored research avenues on how astroglial cannabinoid signaling could affect behavior.

关 键 词：D-丝氨酸 星形胶质细胞 大麻素受体 认知 乳酸 啮齿动物行为 社会行为 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]