经颈静脉肝内门腔分流术联合功能性脾栓塞术治疗肝硬化失代偿期门静脉高压患者的临床疗效观察  

Clinical Efficacy of Transjugular Intrahepatic Portosystemic Shunt Combined with Functional Splenic Embolization in the Treatment of Portal Hypertension in Cirrhotic Decompensated Liver

作　　者：董洋 梁桂杰 王滕 郭义 孙志超 王波 DONG Yang;LIANG Guijie(The Third Hospital of Chengde, Heibei Chengde 067000, China)

机构地区：[1]河北省承德市第三医院放疗二科,河北承德067000 [2]河北省丰宁县医院,河北丰宁068350 [3]河北省承德市卫生健康委员会信息中心,河北承德067000

出　　处：《河北医学》2022年第4期584-588,共5页Hebei Medicine

基　　金：河北省承德市科技支撑计划项目,(编号:202109A005)。

摘　　要：目的:研究经颈静脉肝内门腔分流术(TIPS)联合功能性脾栓塞术(FSE)治疗肝硬化失代偿期门静脉高压的临床疗效。方法:将100例肝硬化门静脉高压患者简单随机分组为对照组和治疗组,对照组予部分性脾动脉栓塞术(PSE),治疗组予经颈静脉肝内门腔分流术(TIPS)及功能性脾栓塞术(FSE)两组患者均行介入手术1次后进行临床疗效评估。主要观察两组患者的门静脉压力、肝功能、脾脏体积、血常规、凝血功能、近期生存期及安全性指标。结果:治疗后治疗组门静脉压力、肝功能、脾脏体积、血常规、凝血功能均优于对照组(P<0.05);两组患者近期生存情况及安全性比较无统计学差异(P>0.05)。结论:经颈静脉肝内门腔分流术(TIPS)联合功能性脾栓塞术(FSE)治疗肝硬化失代偿期门静脉高压具有较好的临床疗效,值得临床推广。Objective:To study the clinical efficacy of transjugular intrahepatic portosystemic shunt(TIPS)combined with functional splenic embolization(FSE)in the treatment of portal hypertension in decompensated cirrhosis.Methods:A total of 100 patients with cirrhotic portal hypertension were randomly divided into control group and treatment group.In the control group,partial splenic artery embolization(PSE)was performed,while in the treatment group,transjugular intrahepatic portosystemic shunt(TIPS)and functional splenic embolization(FSE)were performed.The clinical efficacy of the two groups was evaluated after one intervention.The main observations were portal vein pressure,liver function,spleen volume,blood count,coagulation,recent survival and safety indicators in both groups.Results:After treatment,the portal vein pressure,liver function,spleen volume,blood routine and coagulation function in the treatment group were better than those in the control group(P<0.05);there was no statistical difference between the two groups in terms of recent survival and safety(P>0.05).Conclusion:Transjugular intrahepatic portosystemic shunt(TIPS)combined with functional splenic embolization(FSE)has a good clinical effect in the treatment of portal hypertension in cirrhotic decompensated liver,which is worthy of clinical promotion.

关 键 词：经颈静脉肝内门腔分流术 功能性脾栓塞术 部分性脾动脉栓塞术 肝硬化失代偿期 门静脉高压 

分 类 号：R57[医药卫生—消化系统]