ALDH1A3在肿瘤、血管平滑肌调控中的作用及研究进展  

Advances in the research of the roles of ALDH1A3 in regulating tumor biological characteristics and vascular smooth muscle cell proliferation

作　　者：包燕霞 权金星[2] 董昌宏 姜盼盼 崔亚强 Yan-xia Bao;Jin-xing Quan;Chang-hong Dong;Pan-pan Jiang;Ya-qiang Cui(The First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou,Gansu 730099,China;Department of Endocrinology,Gansu Provincial People's Hospital,Lanzhou,Gansu 730000,China;Clinical Medical College,Ningxia Medical University,Yinchuan,Ningxia 750000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730099 [2]甘肃省人民医院内分泌科,甘肃兰州730000 [3]宁夏医科大学临床医学院,宁夏银川750000

出　　处：《中国现代医学杂志》2022年第8期52-57,共6页China Journal of Modern Medicine

基　　金：国家自然科学基金项目(No:81860091);甘肃省人民医院院内科研项目(No:16GSSY1-1)。

摘　　要：乙醛脱氢酶1A3(ALDH1A3)是醛类代谢酶系醛脱氢酶家族中的重要成员之一,其主要通过将全反式视黄醛氧化成视黄酸,来参与人体细胞的生理过程。大量证据表明ALDH1A3参与调节肿瘤细胞的生物学特性,具有作为癌症诊断和治疗靶点的潜力。ALDH1A3在促进平滑肌细胞的增殖方面发挥作用,可能与动脉粥样硬化的形成密切相关。笔者从ALDH1A3在恶性肿瘤、血管平滑肌调控中的作用及机制等方面进行综述。Aldehyde dehydrogenase family 1 member A3(ALDH1A3)is an important member of the aldehyde dehydrogenase family,and is involved in the physiological process of human cells mainly through the oxidation of all-trans retinal to retinoic acid.ALDH1A3 has the potential to be a target for cancer diagnosis and treatment,as a large body of evidence shows that ALDH1A3 participates in regulating the biological characteristics of tumor cells.Recent studies have found that ALDH1A3 also plays a role in promoting the proliferation of smooth muscle cells,which may be closely related to the development of atherosclerosis.In this review,the role and mechanism of ALDH1A3 in modulating tumor biological characteristics and vascular smooth muscle cell proliferation will be summarized.

关 键 词：肿瘤标志物 血管平滑肌 乙醛脱氢酶1A3 动脉粥样硬化 

分 类 号：R730.5[医药卫生—肿瘤]